The role of AP2β, the molecule which leads to adipocyte hypertrophy, in the metabolic syndrome

为了确定TFAP2B在体内调节脂联素、瘦素和白细胞介素-6 （IL-6）表达中的潜在作用，我们量化了66例个体内脏（网膜）和腹部皮下脂肪组织中这些脂肪因子和TFAP2B的mRNA表达水平，并研究了它们之间的相关性。我们发现TFAP2B mRNA与皮下脂肪组织中脂联素的表达呈负相关。在皮下和网膜脂肪组织中，TFAP2B mRNA表达与瘦素呈负相关，与IL-6表达呈正相关。这些关系与我们在体外的观察结果一致，表明TFAP2B似乎在体内调节多种脂肪因子的表达。

To determine the potential role of TFAP2B in the regulation of expression of adiponectin, leptin and interleukin-6 (IL-6) in vivo, we quantified the mRNA expression levels of these adipokines and TFAP2B in visceral (omental) and abdominal subcutaneous adipose tissues of 66 individuals and studied their correlations. We found that TFAP2B mRNA correlated negatively with adiponectin expression in the subcutaneous adipose tissue. Furthermore, TFAP2B mRNA expression correlated negatively with leptin and positively with IL-6 expression in both subcutaneous and omental adipose tissues. These relationships are consistent with our in vitro observations and indicate that TFAP2B seems to regulate the expression of various adipokines in vivo.