Evaluation and treatment for complications of hematopoietic stem cell transplantation

本研究采用环磷酰胺、阿霉素、长春新碱、泼尼isolong±利妥昔单抗标准化疗后，进行血管紧张素II受体阻滞剂缬沙坦预防慢性心脏毒性损伤的临床试验。本研究表明：(1)降低强度的同种异体干细胞移植（RIST）在心功能障碍患者中耐受性良好；(2)监测HRV可能有助于预测干细胞移植是一种有用的、无创的预测闭塞性细支气管炎综合征（BOS）和特发性肺炎综合征（IPS）发展的指标；(4)心率变异性分析有助于评价和预测外周血干细胞采收过程中心血管并发症的不良反应。

In this study, clinical trial of angiotensin II receptor blocker, Valsartan, to prevent chronic cardiotoxic damage following standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, prednisolong±rituximab was performed. This study shows that (1)reduced-intensity allogeneic stem cell transplantation (RIST) is well-tolerated in patients with cardiac dysfunction ; (2)monitoring HRV may be useful in predicting stem cell transplantation is a useful, noninvasive predictor for the development of bronchiolitis obliterans syndrome (BOS) and idiopathic pneumonia syndrome (IPS) ; (4)heart rate variability analysis is useful in evaluating and predicting the adverse effects of cardiovascular complications in peripheral blood stem cell harvest.