Hematopoietic Stem Cell Transplantation

造血干细胞移植

• 批准号: 23591423
• 负责人: HINO Masayuki
• 金额: $ 3.33万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591423/
• 关键词: 同種造血幹細胞移植; HLA半合致移植; GVHD; 移植後シクロホスファミド; バイオマーカー; 消化管GVHD; ステロイド動注; ベクロメタゾン; 移植後大量シクロホスファミド投与; 移植片対宿主病; 非寛解造血器悪性腫瘍; 類洞閉塞症; 閉塞性細気管支炎; フェリチン; 移植後血球貪食症候群

A myeloablative regimen involved high-dose TBI impaired cardiac function. A high s-ferritin level before HCT might be associated with the development of LVH in the chronic phase of HCT. A high s-ferritin level after HCT might be a prognostic factor. Eosinophilia after allo-HCT was associated with better OS and a lower relapse rate. Dysregulated balance between Th1 and Th2 cytokines might play an important role in the incidence of HPS after allo-HCT. Prospective pilot study of HLA haplo-identical allogeneic PBSCT using cyclophosphamide post-transplantation for patients with a poor-prognosis or refractory leukemia and MDS showed that except for one patient who died due to disease progression, full donor T-cell chimerism was achieved at day 30 in all patients, 53% of patients developed grade II-III acute GVHD, the cumulative incidence of TRM at one year was 13%, and the OS at one year of all patients, patients in remission and those with active disease were 43%, 75% and 31%, respectively.

清除骨髓方案涉及高剂量TBI心功能受损。HCT前高s-铁蛋白水平可能与HCT慢性期LVH的发生有关。HCT后高s-铁蛋白水平可能是一个预后因素。同种异体hct后嗜酸性粒细胞增多与较好的OS和较低的复发率相关。Th1和Th2细胞因子失衡可能在同种异体hct后HPS的发生中起重要作用。预后不良或难治性白血病和MDS患者移植后使用环磷酰胺进行HLA单倍相同同种异体PBSCT的前瞻性前期研究表明，除1例患者因疾病进展死亡外，所有患者在第30天均实现了完全供体t细胞嵌合，53%的患者发展为II-III级急性GVHD， 1年TRM累积发生率为13%，1年OS为所有患者。缓解期和活动性患者分别为43%、75%和31%。

项目成果

Reduced-intensity conditioning by fludarabine/busulfan without additional irradiation or T-cell depletion leads to low non-relapse mortality in unrelated bone marrow transplantation

在不进行额外照射或 T 细胞耗竭的情况下，使用氟达拉滨/白消安降低强度调节可降低无关骨髓移植中的非复发死亡率

• DOI: 10.1007/s12185-011-0805-z
• 发表时间: 2011
• 期刊: Int J Hematol
• 影响因子: 2.1
• 作者: Nakane T;Nakamae H;Koh H;Nakamae M;Hayashi Y;Nishimoto M;Yoshimura T;Inoue E;Inoue A;Aimoto R;Aimoto M;Terada Y;Koh KR;Yamane T;Hino M
• 通讯作者: Hino M

Risk factors affecting cardiac left-ventricular hypertrophy and systolic and diastolic function in the chronic phase of allogeneic hematopoietic cell transplantation.

影响异基因造血细胞移植慢性期心脏左心室肥厚及收缩舒张功能的危险因素。

• DOI: 10.1038/bmt.2012.179
• 发表时间: 2013
• 期刊: Bone Marrow Transplant
• 作者: Nishimoto M;Nakamae H;Koh H;Nakane T;Nakamae M;Hirose A;Hagihara K;Nakao Y;Terada Y;Ohsawa M;Hino M.
• 通讯作者: Hino M.

非血縁者間末梢血幹細胞採取

无关个体之间的外周血干细胞采集

• 发表时间: 2012
• 期刊: 日本アフェレーシス学会雑誌
• 作者: Kodama T;Tadokor o S;Tomiyama Y他14名;日野雅之
• 通讯作者: 日野雅之

Eosinophilia, regardless of degree, is related to better outcomes after allogeneic hematopoietic stem cell transplantation.

嗜酸性粒细胞增多，无论程度如何，都与异基因造血干细胞移植后更好的结果相关。

• 发表时间: 2012
• 期刊: Intern Med
• 作者: Nakane T;Nakamae H;Hirose A;Nakamae M;Koh H;Hayashi Y;Nishimoto M;Umemoto Y;Yoshimura T;Bingo M;Okamura H;Yoshida M;Ichihara H;Aimoto M;Terada Y;Nakao Y;Ohsawa M;Hino M.
• 通讯作者: Hino M.

同種造血幹細胞移植後慢性期における心機能障害リスク因子の評価

异基因造血干细胞移植后慢性期心功能不全危险因素评价

• 发表时间: 2012
• 作者: 西本光孝;中前博久;中根孝彦;康秀男;林良樹;中前美佳;吉田全宏;備後真登;岡村浩史;相本瑞樹;間部賢寛;吉村卓朗;稲葉晃子;南野智;廣瀬朝生;萩原潔通;中尾吉孝;寺田芳樹;日野雅之
• 通讯作者: 日野雅之