FOXP3 isoform expression in the regulatory T cells in systemic lupus erythematosus patients and its role in the mechanism of the immue suppression

系统性红斑狼疮患者调节性T细胞FOXP3亚型的表达及其在免疫抑制机制中的作用

• 批准号: 19591177
• 负责人: SUZUKI Katsuya
• 金额: $ 2.91万
• 依托单位: Saitama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591177/
• 关键词: 全身性エリテマトーデス; T細胞; 制御性T細胞; FOXP3; アイソフォーム免疫寛容; アイソフォーム; 免疫寛容

In patient with systemic lupus erythematosus (SLE), gene expression of both FOXP3 and its isoform, which express in regulatory T cell (Treg) that play an important role in immune tolerance, were decreased. These results indicated that both are important as a cause in immune tolerance in SLE. Next we investigated FOXP3 expression in immune suppressive state and found that decreased Treg subpopulation was not natural but induced Treg. From our study, we obtained important clues on the effective therapeutic target for SLE.

在系统性红斑狼疮（SLE）患者中，在免疫耐受中起重要作用的调节性T细胞（Treg）中表达的FOXP3及其亚型的基因表达均降低。这些结果表明，两者都是SLE免疫耐受的重要原因。接下来，我们研究了免疫抑制状态下FOXP3的表达，发现减少的Treg亚群不是自然的，而是诱导的Treg。本研究为SLE的有效治疗靶点提供了重要线索。

项目成果

Effect of interleukin-2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells

• DOI: 10.1016/j.cyto.2008.06.005
• 发表时间: 2008-10-01
• 期刊: CYTOKINE
• 影响因子: 3.8
• 作者: Suzuki, Katsuya;Setoyama, Yumiko;Takeuchi, Tsutomu
• 通讯作者: Takeuchi, Tsutomu

T細胞に対するイムノロジカ ルインターベンション

T细胞的免疫干预

• 发表时间: 2009
• 作者: 鈴木勝也;瀬戸山由美子;竹内勤;鈴木勝也;鈴木勝也
• 通讯作者: 鈴木勝也

Immunological intervention for systemic lupus erythematosus, Seminar

系统性红斑狼疮免疫干预研讨会

• 发表时间: 2009
• 作者: Nakamura S;Yang C-S;Sakon N;Ueda M;Tougan T;Yamashita A;Goto N;Takahashi K;Yasunaga T;Ikuta K;Mizutani T;Okamoto Y;Tagami M;Morita R;Maeda N;Kawai J;Hayashizaki Y;Nagai Y;Horii T;Iida T;Nakaya T.;Suzuki K
• 通讯作者: Suzuki K

Regulatory T cells and FOXP3 isoform expression in patients with systemic lupus erythematosus and rheumatoid arthritis

系统性红斑狼疮和类风湿性关节炎患者中调节性 T 细胞和 FOXP3 亚型的表达

• 发表时间: 2007
• 作者: Hagiwara K;Kadosawa T;and Nakaya T;Suzuki K;鈴木勝也
• 通讯作者: 鈴木勝也

Single Center Prospective Study of Tacrolimus Efficacy and Safety in Treatment of Rheumatoid Arthritis

他克莫司治疗类风湿关节炎疗效和安全性的单中心前瞻性研究

• 发表时间: 2009
• 期刊: Rheum. Int 29(4)
• 作者: Suzuki K;Kameda H;Amano K;Nagasawa H;Takei H;Sekiguchi N;Nishi E;Ogawa H;Tsuzaka K;Takeuchi T
• 通讯作者: Takeuchi T