FOXP3 isoform expression in the regulatory T cells in systemic lupus erythematosus patients and its role in the mechanism of the immue suppression

在系统性红斑狼疮(SLE)患者中，在免疫耐受中起重要作用的调节性T细胞(Treg)表达的FOXP3及其异构体基因表达均降低。这些结果表明，两者都是导致SLE免疫耐受的重要原因。接下来，我们研究了FOXP3在免疫抑制状态下的表达，发现Treg亚群的减少不是自然的，而是诱导的。本研究为寻找治疗SLE的有效靶点提供了重要线索。

In patient with systemic lupus erythematosus (SLE), gene expression of both FOXP3 and its isoform, which express in regulatory T cell (Treg) that play an important role in immune tolerance, were decreased. These results indicated that both are important as a cause in immune tolerance in SLE. Next we investigated FOXP3 expression in immune suppressive state and found that decreased Treg subpopulation was not natural but induced Treg. From our study, we obtained important clues on the effective therapeutic target for SLE.