MicroRNA profiling of human lupus nephritis and murine lupus-like nephritis.

人类狼疮性肾炎和小鼠狼疮样肾炎的 MicroRNA 分析。

• 批准号: 19591167
• 负责人: KAWANO Seiji
• 金额: $ 2.91万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591167/
• 关键词: 膠原病学; ループス腎炎; PD-1; トレランス; マイクロRNA; NZB; W F1; ループス賢炎

NZB/W F1マウスに抗PD-1抗体と抗PD-L1抗体の投与実験を行い、前者はCD4+PD-1+T細胞を減らして腎炎を改善し、後者は逆にCD4+PD-1+T細胞が蓄積し腎炎を悪化させた。CD4+PD-1+T細胞はIFN-γ高産生細胞であり、腎炎病態への積極的関与が強く示唆された。また同マウスの抗PD-L1抗体投与後に、脾臓から単離したCD4+PD-1+T細胞とCD4+PD-1-T細胞よりmiRNAおよびmRNAを抽出し、比較プロファイリングを行ってCD4+PD-1+T細胞に特異的なmiRNAおよびmRNAの同定を試みた。

NZB/WF1 antibody and anti-PD-L1 antibody administration, the former CD4 + PD-1 +T cell reduction to improve nephritis, the latter reverse CD4 + PD-1 + T cell accumulation to reduce nephritis CD4 + PD-1 +T cells are highly IFN-γ producing cells, which are associated with positive and strong expression of glomerulonephritis pathologies. After administration of anti-PD-L1 antibody, the mRNA expression of CD4 + PD-1 +T cells and CD4 + PD-1-T cells was isolated and compared with that of CD4 + PD-1 +T cells.

项目成果

Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in the salivary glands of patients with Sjogren's syndrome

硫氧还蛋白可能对干燥综合征患者唾液腺氧化应激引起的组织损伤发挥保护作用

• 发表时间: 2007
• 期刊: Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in the salivary glands of patients with Sjogren's syndrome 34
• 作者: Kurimoto C;Kawano S;Tsuji G;Hatachi S;Jikimoto T;Sugiyama D;Kasagi S;Komori T;Nakamura H;Yodoi J;and Kumagai S
• 通讯作者: and Kumagai S

Expression of PD-1/PD-L1 in the development of lupus-like nephritis in NZB/W mice.

PD-1/PD-L1 在 NZB/W 小鼠狼疮样肾炎发生过程中的表达。

• 发表时间: 2007
• 作者: 笠木伸平;他
• 通讯作者: 他

Involvement of IFN-g producing CD4+ PD-1+ T cells in lupus-prone NZB/W F1 mice

狼疮易发性 NZB/W F1 小鼠中产生 IFN-g 的 CD4 PD-1 T 细胞的参与

• 发表时间: 2008
• 作者: Kasagi S;et.al.
• 通讯作者: et.al.

MicroRNA-124a Is a Key Regulator of Proliferation and Monocyte Chemoattractant Protein 1 Secretion in Fibroblast-like Synoviocytes From Patients With Rheumatoid Arthritis

• DOI: 10.1002/art.24475
• 发表时间: 2009-05-01
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Nakamachi, Yuji;Kawano, Seiji;Kumagai, Shunichi
• 通讯作者: Kumagai, Shunichi

HLA-DR-negative AML (M1 and M2): FLT3 mutations (ITD and D835) and cell-surface antigen expression

• DOI: 10.1016/j.leukres.2006.09.017
• 发表时间: 2007-07-01
• 期刊: LEUKEMIA RESEARCH
• 影响因子: 2.7
• 作者: Syampurnawati, Mellam;Tatsumi, Eiji;Hayashi, Yoshitake
• 通讯作者: Hayashi, Yoshitake