Analyses of reduced brain injury by treatment with neural stem /progenitor cells together with chondroitinase.
Analyses of reduced brain injury by treatment with neural stem /progenitor cells together with chondroitinase.
批准号:
19591290
负责人:
NAKANISHI Keiko
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
Administration of neural stem/progenitor cells (NSPCs) with chondroitinase (CHase) reduced brain injury in a neonatal hypoxic-ischemic rat model. To investigate its mechanism, we established in vitro hypoxic-ischemic model. GFP-transgenic rat neurons were cultured and exposed to oxygen-glucose depletion (OGD). Treatment with NSPCs combined with CHase was tended to reduce OGD-induced neuronal cell death. We are currently trying to find the factors regulating neuroprotection using this model.
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The fifth splice variant of neuroglycan C, a CNS-specific transmembrane chondroitin sulfate proteoglycan
神经聚糖 C 的第五种剪接变体,一种中枢神经系统特异性跨膜硫酸软骨素蛋白聚糖
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[青野幸子, 鈴木敦史, 時田義人, 中西圭子, 伊田みちる, 松井ふみ子, 大平敦彦]
通讯作者:
大平敦彦
生化学(中枢神経系に特異的に発現するコンドロイチン硫酸プロテオグリカン、ニューログリカンCの機能, 79)
生物化学(神经聚糖 C 的功能,一种在中枢神经系统中特异性表达的硫酸软骨素蛋白聚糖,79)
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[中西圭子, 大平敦彦]
通讯作者:
大平敦彦
Role of Neuroglycan C, a Brain-specific Proteoglycan, in Neuronal Development
Neuroglycan C(一种脑特异性蛋白多糖)在神经元发育中的作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Tokita Y, Aono S, Matsui F, Nakanishi K, Oohira A]
通讯作者:
Oohira A
NICU退院児に対する広汎生発達障害早期発見プログラムの開発-第3報-
为新生儿重症监护病房出院的儿童制定早期发现广泛性发育障碍的计划 - 第三次报告 -
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[山田恭聖, 中西圭子, ら]
通讯作者:
ら
Neuroprotective effect of nipradilol,an NO donor,on hypoxic-ischemic brain injury of neonatal rats
NO供体尼普地洛对新生大鼠缺氧缺血性脑损伤的神经保护作用
DOI:
--
发表时间:
2007
期刊:
Early Hum Dev 83
影响因子:
--
作者:
[Kakizawa H, et. al.]
通讯作者:
et. al.
共 33 条
Umbilical cord blood-derived cell therapy for perinatal brain damage
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批准号:22591213
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
-
财政年份:2010
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负责人:NAKANISHI Keiko
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依托单位:
An Examination of Tsung-mi's Teaching with reference to the Historical Interaction of the Buddhism, Confucianism and Taoism during the T'ang Dynasty
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批准号:12610014
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.51万
-
财政年份:2000
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负责人:NAKANISHI Keiko
-
依托单位:
Functional synapse formation in cultured neocortical neurons from prenatal X-irradiated rats.
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批准号:11671078
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:1999
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负责人:NAKANISHI Keiko
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依托单位:
海外基金