Investigation on the methods that will overcome crossing-fiber problem of diffusion tensor tractography.

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The purpose of this investigation was to conduct a research on methods that will overcome the crossing-fiber problem on diffusion-tensor tractography. More specifically, we tested the feasibility of using high angular resolution diffusion imaging (HARDI)-based multi-tensor tractography to depict motor pathways. We tested this on patients with brain tumors. Ten patients were scanned using a 1.5T clinical MR unit. Data postprocessing was performed using both the conventional single- and multi-tensor methods. Motor fibers on both lesional and contralesional sides were successfully depicted by both the single-tensor and multi-tensor techniques. However, with the single-tensor model, the depiction of motor pathways was typically limited to the fibers of trunk areas. We also assessed the value of using high b-factor. This investigation indicated that the b factor between 1000 and 3000 will have less effect on the depiction of crossing fibers.