Q-space imaging for brain microarchitecture analysis

Q-Space成像是一种新的磁共振(MR)技术，能够评估脑白质的超微结构变化。我们推测，这项技术将有助于评估常染色体显性遗传性脑动脉病合并皮质下梗塞和白质脑病(CADASIL)所见的神经元损害的进行性。Q-Space成像显示早期神经元损伤呈特征性分布。由于这种方法似乎对早期神经元损伤很敏感，可以想象它可以帮助监测临床前阶段的患者，并可能有助于评估未来医疗干预的效果。

q-Space imaging is a novel magnetic resonance (MR) technique that enables the assessment of ultrastructural changes of white matter. We hypothesized that thistechnique would facilitate the assessment of the progressive nature of neuronal damage seen in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). q-Space imaging demonstrated early neuronaldamage in a characteristic distribution. Since this method appears to be sensitive to early neuronal damage, it could conceivably aid in monitoring patients in the preclinical stage and may help in assessing the effects of future medical interventions.