A novel chemoradiotherapy prolonging intratumoral retention of anticancer drugs by interrupting tumor blood flow

照射后肿瘤血流量增加，血管通透性增强，药物对肿瘤组织的输送明显增强。药物在肿瘤组织中的滞留时间最大增加一倍。即使在肿瘤血流完全阻断的情况下，小分子药物(小于4000)也会通过扩散从肿瘤组织中被洗出。本研究中最重要的发现是肿瘤血流阻断的时机是影响放射治疗疗效的决定性因素。

Drug delivery to tumor tissues was markedly enhanced by an increase in tumor blood flow accompanied with enhanced vascular permeability after irradiation. The increase in drug retention time in the tumor tissues was double at the maximum. Low molecular weight drugs (less than 4000) were washed out from the tumor tissue by diffusion even in the condition of complete tumor blood flow interruption. The most important finding obtained in the present study was that the timing of tumor blood flow interruption is a determinant influencing the efficacy of radiotherapy.