Efficacy of microwave hyperthermia under condition of decrease in tumor blood flow

肿瘤血流减少条件下微波热疗的疗效

• 批准号: 09670912
• 负责人: HORI Katsuyoshi
• 金额: $ 1.34万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670912/
• 关键词: hyperthermia; microwave; tumor blood flow; angiotensin converting enzyme inhibitor; angiotensin II receptor type I antagonist; combretastatin A-4

The efficacy of hyperthermia therapy is strongly dependent on temperature. However, current hyperthermia equipment including microwave apparatus have revealed an inability to uniformly raise tumor temperatures to above 42ﾟC.It has been considered that one approach to increasing temperatures in the tumors is to lower tissue blood flow thereby decreasing heat loss from the tumor and concurrent lyincreasing temperatures. In this study, we tried to find new materials which induce tumor blood flow reduction and using the material we investigated efficacy of microwave hyperthermia under condition of decrease in tumor blood flow. We obtained the following two results.1. We discovered that temocapril hydrochloride, an angiotensin converting enzyme inhibitor, losartan, angiotensin II receptor type 1 antagonist, and AC7700, a soluble combretastatin A4 derivative decrease tumor tissue blood flow selectively. In particular, AC7700 induced irreversible stoppage of tumor bloodflow.2. Therapeutic efficacy of microwave hyperthermia on tumors with the volume of above 5 cm3 was not enhanced by decreasing tumor tissue blood flow due to temocapril hydrochloride.

热疗的疗效强烈依赖于温度。然而，包括微波设备的当前热疗设备已经显示出不能将肿瘤温度均匀地升高到42 ° C以上。已经认为，增加肿瘤中的温度的一种方法是降低组织血流，从而减少来自肿瘤的热损失和同时增加的温度。本研究试图寻找新的肿瘤血流量减少材料，并利用该材料研究在肿瘤血流量减少的情况下微波热疗的效果。我们得到了以下两个结果。1.我们发现，血管紧张素转换酶抑制剂盐酸替莫普利、血管紧张素II受体1型拮抗剂洛沙坦和可溶性考布他汀A4衍生物AC 7700选择性地减少肿瘤组织血流量。特别是，AC 7700诱导了肿瘤血流的不可逆停止。微波热疗对体积大于5cm ~ 3的肿瘤的疗效并不因盐酸替莫普利降低肿瘤组织血流量而增强。

项目成果

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Li H-C：“荷瘤大鼠在有效化疗后出现高凝状态和弥散性血管内凝血。”

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Kubota K：“18F-氟米索硝唑、脱氧葡萄糖和蛋氨酸在肿瘤组织中分布的比较。”

LiH-C: "Hypercoagulable state and disseminated intravascular coagulation following an effective chemotherapy in tumor-bearing rats." Chiness Medical Journal. 111. 951-955 (1998)

LiH-C：“荷瘤大鼠在有效化疗后出现高凝状态和弥散性血管内凝血。”