Analysis of the CD80 up-regulation by low-dose ionizing radiation.

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We have previously demonstrated irradiation-induced up-regulation of CD80 expression in B lymphoma cells such as A20-HL cells. However, the mechanism of this up-regulation is unknown. In this present study, we investigated whether low-dose exposure of irradiation induces CD80 expression in mouse splenic B cells and bone marrow cells derived dendritic cells (BMDC). Selective CD80 up-regulation not only in splenic B cells but also in BMDCs. The up-regulation of CD80 expression was accompanied with nuclear factor-kB activation (NF-kB). The activation-pathway in splenic B cells was dependent on the generation of reactive oxygen species, while that in A20-HL cells and BMDCs were not.