Development of a less invasive treatment for varicose veins with high intensity focused ultrasound

开发利用高强度聚焦超声微创治疗静脉曲张的方法

• 批准号: 19591474
• 负责人: MIYATA Tetsuro
• 金额: $ 2.58万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591474/
• 关键词: HIFU; 下肢静脈瘤; 無侵襲治療; レボビスト

The basic studies to develop a less invasive treatment for varicose veins with HIFU were performed. When HIFU was exposed to the dilatate vein, the enough heat dose to denature the vein was not gained. When the vein was compressed to remove the internal liquid, the significant coagulated necrosis of the vein was generated. In order to consider the exposure parameters for in-vivo experiment, the temperature distribution was predicted with bio-heat transfer equation. Then, the subcutaneous injection was useful to improve the location between epidermis and the focus of HIFU. With the result of their experiment, the coagulate necrosis of external jugular vein was generated without skin burn.

对使用HIFU进行静脉曲张静脉的侵入性治疗较少的基础研究。当HIFU暴露于扩张静脉时，足够的热剂量可以使静脉不增加。当静脉被压缩以去除内部液体时，会产生明显的凝结坏死。为了考虑用于体内实验的暴露参数，使用生物热传递方程式预测温度分布。然后，皮下注射可用于改善表皮和HIFU焦点之间的位置。通过实验的结果，产生了颈外静脉的凝结坏死，而没有皮肤灼伤。

项目成果

High Intensity Focused Ultrasound (HIFU : 集束超音波) を用いた非侵襲的静脈瘤治療

使用高强度聚焦超声 (HIFU) 进行无创静脉曲张治疗

• 发表时间: 2010
• 作者: 鈴木潤;宮田哲郎;ほか
• 通讯作者: ほか

Development of Noninvasive Vascular Occlusion Method With HIFU

HIFU 无创血管闭塞方法的发展

• 发表时间: 2009
• 作者: Naohiko Senoo;Jun Suzuki;Kiyoshi Yoshinaka;Juno Deguchi;Shu Takagi;Tetsuro Miyata;Yoichiro Matsumoto
• 通讯作者: Yoichiro Matsumoto

Objective Assessment of Nerve Injury after Greater Saphenous Vein Stripping

大隐静脉剥离术后神经损伤的客观评估

• 发表时间: 2007
• 期刊: Eur J Vasc Endovasc Surg 33
• 作者: Matsushita;K.;Tomonaga;T.;Kajiwara,T.;Shimada;H.;Itoga;S.;Hiwasa;T.;Kubo;S.;Ochiai;T.;Matsubara;H. and Nomura;F;D. Akagi
• 通讯作者: D. Akagi

集束超音波を用いた非侵襲血管閉塞手法の開発

聚焦超声无创血管闭塞方法的开发

• 发表时间: 2009
• 作者: 妹尾直彦;鈴木潤;葭仲潔;出口順夫;高木周;宮田哲郎;松本洋一郎
• 通讯作者: 松本洋一郎