Development of a less invasive treatment for varicose veins with high intensity focused ultrasound

本文进行了微创HIFU治疗静脉曲张的基础研究。当HIFU暴露于扩张静脉时，没有获得足够的热剂量使静脉变性。当静脉被压缩以清除内部液体时，静脉产生明显的凝固性坏死。为了考虑体内实验的暴露参数，用生物传热方程预测了温度分布。皮下注射有助于改善HIFU的表皮与病灶之间的位置。实验结果表明，在没有皮肤烧伤的情况下，产生了颈外静脉凝固性坏死。

The basic studies to develop a less invasive treatment for varicose veins with HIFU were performed. When HIFU was exposed to the dilatate vein, the enough heat dose to denature the vein was not gained. When the vein was compressed to remove the internal liquid, the significant coagulated necrosis of the vein was generated. In order to consider the exposure parameters for in-vivo experiment, the temperature distribution was predicted with bio-heat transfer equation. Then, the subcutaneous injection was useful to improve the location between epidermis and the focus of HIFU. With the result of their experiment, the coagulate necrosis of external jugular vein was generated without skin burn.