Analysis of liver regeneration and liver fibrosis focusing on mechanical stress

以机械应力为重点的肝再生和肝纤维化分析

• 批准号: 19591606
• 负责人: IIMURO Yuji
• 金额: $ 2.91万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591606/
• 关键词: 再生医学; 細胞・組織; 流体工学; シミュレーション

ヒトにおける切除後肝再生のメカニズムをメカニカルストレス応答の面から解析し、相対的門脈血流量の増加(相対的ストレス増加)が、領域別肝再生を制御している可能性が明らかとなった。また、肝臓におけるメカニカルストレス受容体の存在が具体的に示唆された。

The possibility of controlling liver regeneration by domain is clear because of the increase of portal blood flow (increase of portal blood flow). The existence of a receptor is a specific indication of the presence of a receptor.

项目成果

Computational flow dynamics simulation of portal branches is useful for analyzing the mechanism of non-uniform regional liver regeneration after surgical resection.

门静脉分支的计算流动力学模拟有助于分析手术切除后局部肝再生不均匀的机制。

• 发表时间: 2007
• 作者: Yuji Iimuro;Shin-ichi Saito;Jun-ichi Yamanaka;Tadamichi Hirano;Nobukazu Kuroda;Toshihiro Okada;Takaaki Sugimoto;Yasukane Asano;Naoki Uyama;Yugo Uda;Jiro Fujimoto.
• 通讯作者: Jiro Fujimoto.

Non-uniform regional liver regeneration after hepatic surgery well correlates with computationally simulated increases in blood flow and pressure in portal branches.

肝手术后区域肝再生的不均匀与计算模拟的门静脉分支血流和压力的增加密切相关。

• 发表时间: 2008
• 期刊: Journal of Hepatology 48, 2, suppl
• 作者: Yuji Iimuro;et al.
• 通讯作者: et al.

Computational flow dynamics simulation of portal branches is useful for analyzing the mechanism of non-uniform regional liver regeneration after surgical resection

门静脉分支的计算流动力学模拟有助于分析手术切除后局部肝再生不均匀的机制

• 发表时间: 2007
• 期刊: Hepatology 46,4,suppl
• 作者: Yuji Iimuro;et. al.
• 通讯作者: et. al.

Non-uniform increases in blood flow and pressure in porta branches after liver surgery assessed by computational flow dynamics simulation Well correlate with the regional liver regeneration

通过计算血流动力学模拟评估肝脏手术后门支血流和压力的不均匀增加与区域肝再生密切相关

• 发表时间: 2008
• 期刊: Hepatology International 2
• 作者: Yuji Iimuro;et. al.
• 通讯作者: et. al.

Non-uniform increases in blood flow and pressure in portal branches after liver surgery assessed by computational flow dynamics simulation well correlate with the regional liver regeneration.

通过计算血流动力学模拟评估肝脏手术后门静脉分支血流和压力的不均匀增加与区域肝脏再生密切相关。

• 发表时间: 2008
• 作者: Yuji Iimuro;Shin-ichi Saito;Jun-ichi Yamanaka;Tadamichi Hirano;Nobukazu Kuroda;Toshihiro Okada;Takaaki Sugimoto;Yasukane Asano;Naoki Uyama;Yugo Uda;Jiro Fujimoto.
• 通讯作者: Jiro Fujimoto.