Analysis of liver regeneration and liver fibrosis focusing on mechanical stress
Analysis of liver regeneration and liver fibrosis focusing on mechanical stress
批准号:
19591606
负责人:
IIMURO Yuji
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
ヒトにおける切除後肝再生のメカニズムをメカニカルストレス応答の面から解析し、相対的門脈血流量の増加(相対的ストレス増加)が、領域別肝再生を制御している可能性が明らかとなった。また、肝臓におけるメカニカルストレス受容体の存在が具体的に示唆された。
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Computational flow dynamics simulation of portal branches is useful for analyzing the mechanism of non-uniform regional liver regeneration after surgical resection.
门静脉分支的计算流动力学模拟有助于分析手术切除后局部肝再生不均匀的机制。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Jiro Fujimoto.]
通讯作者:
Jiro Fujimoto.
Non-uniform regional liver regeneration after hepatic surgery well correlates with computationally simulated increases in blood flow and pressure in portal branches.
肝手术后区域肝再生的不均匀与计算模拟的门静脉分支血流和压力的增加密切相关。
DOI:
--
发表时间:
2008
期刊:
Journal of Hepatology 48, 2, suppl
影响因子:
--
作者:
[Yuji Iimuro, et al.]
通讯作者:
et al.
Computational flow dynamics simulation of portal branches is useful for analyzing the mechanism of non-uniform regional liver regeneration after surgical resection
门静脉分支的计算流动力学模拟有助于分析手术切除后局部肝再生不均匀的机制
DOI:
--
发表时间:
2007
期刊:
Hepatology 46,4,suppl
影响因子:
--
作者:
[Yuji Iimuro, et. al.]
通讯作者:
et. al.
Non-uniform increases in blood flow and pressure in porta branches after liver surgery assessed by computational flow dynamics simulation Well correlate with the regional liver regeneration
通过计算血流动力学模拟评估肝脏手术后门支血流和压力的不均匀增加与区域肝再生密切相关
DOI:
--
发表时间:
2008
期刊:
Hepatology International 2
影响因子:
--
作者:
[Yuji Iimuro, et. al.]
通讯作者:
et. al.
Non-uniform increases in blood flow and pressure in portal branches after liver surgery assessed by computational flow dynamics simulation well correlate with the regional liver regeneration.
通过计算血流动力学模拟评估肝脏手术后门静脉分支血流和压力的不均匀增加与区域肝脏再生密切相关。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Jiro Fujimoto.]
通讯作者:
Jiro Fujimoto.
共 7 条
Role of splenomegaly in liver fibrosis and hepatocarcinogeneis
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批准号:17K10507
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2017
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负责人:IIMURO Yuji
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依托单位:
The role of non-parenchymal cells in the liver tissue remodeling.
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批准号:25461966
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2013
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负责人:IIMURO Yuji
-
依托单位:
Investigation of the central role of hepatic stellate cells in the tissue-repairing process of the liver
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批准号:22591510
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
-
财政年份:2010
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负责人:IIMURO Yuji
-
依托单位:
Role of TLR signaling and chemokine in liver regeneration, and their application to accelerated regeneration
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批准号:16390385
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.15万
-
财政年份:2004
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负责人:IIMURO Yuji
-
依托单位:
Reconstruction of cirrhotic liver by means of extracellular matrix remodeling and differential stimulation of stem cells.
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批准号:14370394
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.96万
-
财政年份:2002
-
负责人:IIMURO Yuji
-
依托单位:
Role of "shear stress" in initiation of liver regeneration
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批准号:12470262
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.96万
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财政年份:2000
-
负责人:IIMURO Yuji
-
依托单位:
Acceleration of liver regeneration by gene transfer with matrix metalloproteinase (MMP)-1
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批准号:10470256
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.81万
-
财政年份:1998
-
负责人:IIMURO Yuji
-
依托单位:
海外基金