Investigation of the central role of hepatic stellate cells in the tissue-repairing process of the liver

肝星状细胞在肝脏组织修复过程中的核心作用的研究

• 批准号: 22591510
• 负责人: IIMURO Yuji
• 金额: $ 2.83万
• 依托单位: Hyogo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591510/
• 关键词: 肝臓外科学; 肝類洞内皮細胞; 門脈血流; 肝再生; 肝星細胞; 流体解析

The role of non-parenchymal hepatic cells, especially hepatic stellate cells and sinusoidal endothelial cells, in liver regeneration process was investigated focusing on the identification of mechanical stress-receptors on these cells. Meanwhile, relationship between the perioperative change in portal hemodynamics and the regional liver regeneration was analyzed in humans who underwent hepatic surgery. As a result, regional liver regeneration was not homogeneous after hepatic resection, and well correlated with preceding changes in portal flow distribution in each patient. Moreover, several mechanical stress-receptors were identified in resected human liver tissues, and existence of signal transduction pathways under the receptors was suspected by identification of some proteins.

本研究以肝星状细胞和肝窦内皮细胞为主要研究对象，探讨了非实质性肝细胞在肝再生过程中的作用。同时，分析肝手术患者围手术期门静脉血流动力学变化与局部肝再生的关系。因此，肝切除术后局部肝再生并不均匀，并且与每个患者门静脉血流分布的先前变化密切相关。此外，在切除的人肝组织中鉴定了几种机械应力受体，并通过鉴定一些蛋白质怀疑受体下存在信号转导途径。

项目成果

Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/99m Tc-GSA SPECT fusion images correlates well with postoperative liver function parameters

• DOI: 10.1007/s00534-010-0264-6
• 发表时间: 2010-09-01
• 期刊: JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
• 影响因子: 3
• 作者: Iimuro, Yuji;Kashiwagi, Toru;Fujimoto, Jiro
• 通讯作者: Fujimoto, Jiro

流れ"による肝再生制御-ヒト肝切除症例における門脈流体解析と肝再生-

以“流”控制肝再生——人肝切除病例门静脉液分析与肝再生——

• 发表时间: 2011
• 作者: Takeba Y;Matsumoto N;Nakano H;Kobayashi S;et al.;飯室勇二
• 通讯作者: 飯室勇二

Primary squamous cell carcinoma of the liver: an uncommon finding in contrast-enhanced ultrasonography imaging.

• DOI: 10.1159/000334425
• 发表时间: 2011-09
• 期刊: Case reports in gastroenterology
• 影响因子: 0.6
• 作者: Iimuro Y;Asano Y;Suzumura K;Yada A;Hirano T;Iijima H;Nishiguchi S;Hirota S;Fujimoto J
• 通讯作者: Fujimoto J

Preceded Laparoscopic Splenectomy is Useful for Hepatic Resection in HCC with Severe Hypersplenism and Impaired Liver Function.

先前的腹腔镜脾切除术对于患有严重脾功能亢进和肝功能受损的 HCC 的肝切除术很有用。

• 发表时间: 2012
• 作者: 久野隆史;松原長秀;津田聰司;馬場谷彰仁;濱中美衣;山岸大介;塚本潔;山野智基;野田雅史;吉澤恵;田村和朗;冨田尚裕;Iimuro Y
• 通讯作者: Iimuro Y

Prediction of regional liver regeneration in human at the late-phase of surgery based on the simulation of portal blood flow change at postoperative early period.

基于术后早期门静脉血流变化的模拟对人体手术后期局部肝再生的预测

• 发表时间: 2010
• 作者: 中野浩;他;中野浩;Iimuro Y
• 通讯作者: Iimuro Y