Investigation of the central role of hepatic stellate cells in the tissue-repairing process of the liver

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The role of non-parenchymal hepatic cells, especially hepatic stellate cells and sinusoidal endothelial cells, in liver regeneration process was investigated focusing on the identification of mechanical stress-receptors on these cells. Meanwhile, relationship between the perioperative change in portal hemodynamics and the regional liver regeneration was analyzed in humans who underwent hepatic surgery. As a result, regional liver regeneration was not homogeneous after hepatic resection, and well correlated with preceding changes in portal flow distribution in each patient. Moreover, several mechanical stress-receptors were identified in resected human liver tissues, and existence of signal transduction pathways under the receptors was suspected by identification of some proteins.