Development of New Generation of Coronary Stent for The Prevention of Subacute In-Stent Thrombosis and Restenosis

开发新一代预防亚急性支架内血栓形成和再狭窄的冠状动脉支架

• 批准号: 19790538
• 负责人: KAWATA Hiroyuki
• 金额: $ 2.38万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790538/
• 关键词: 急性冠症候群; 亜急性血栓性閉塞; 慢性期再狭窄; 冠動脈ステント; 遺伝子導入; CD39

ヒトCD39遺伝子を導入したカチオン化ゼラチンコーティングステントを作製し,ウサギ急性動脈血栓症モデルの傷害血管に留置することにより,傷害血管にヒトCD39遺伝子を導入し,CD39蛋白発現を増加し得ることが確認できた.また,ステント留置7日まで遺伝子発現およびCD39蛋白活性を正常血管と同程度に維持することが可能であり,ステント留置後の亜急性期ステント内血栓症が完全に抑制され,さらに血管平滑筋細胞の増殖が抑制され,再内皮化を促進し得ることが確認できた.

CD39 protein expression was confirmed by the introduction of CD39 protein into the blood vessels of patients with acute thrombosis. It is possible that the expression of CD39 protein in normal blood vessels and the maintenance of CD39 protein activity in normal blood vessels after 7 days of detention were completely inhibited, and the proliferation of vascular smooth muscle cells was inhibited and reendothelialization was promoted.

项目成果

Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation

• DOI: 10.1007/s00380-008-1053-x
• 发表时间: 2008-09-01
• 期刊: HEART AND VESSELS
• 影响因子: 1.5
• 作者: Horii, Manabu;Uemura, Shiro;Saito, Yoshihiko
• 通讯作者: Saito, Yoshihiko

ANP is cleared much faster than BNP in patients with congestive heart failure

• DOI: 10.1007/s00228-007-0309-1
• 发表时间: 2007-07-01
• 期刊: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
• 影响因子: 2.9
• 作者: Kimura, Kuniko;Yamaguchi, Yukinari;Saito, Yoshihiko
• 通讯作者: Saito, Yoshihiko

Ultrasound accelerates thrombolysis of acutely induced platelet-rich thrombi similar to those in acute myocardial infarction

• DOI: 10.1253/circj.71.1643
• 发表时间: 2007-10-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Kawata, Hiroyuki;Naya, Noriyuki;Saito, Yoshihiko
• 通讯作者: Saito, Yoshihiko

Human Placental Ectonucleoside Triphosphate Diphosphohydrolase Gene Transfer via Gelatin-Coated Stents Prevents In-Stent Thrombosis

通过明胶涂层支架进行人胎盘外核苷三磷酸二磷酸水解酶基因转移可预防支架内血栓形成

• 发表时间: 2009
• 期刊: Arterioscler Thromb Vasc Biol. 29
• 作者: Takemoto Y;Matsumoto M;他11名
• 通讯作者: 他11名

Development of the new gene-eluting stent that prevents subacute in-stent thrombosis by enhancing E-NTPDase activity in injured artery

开发新型基因洗脱支架，通过增强受损动脉中的 E-NTPDase 活性来预防亚急性支架内血栓形成

• 发表时间: 2008
• 作者: Takemoto Y;Kawata H;Imagawa K;Soeda T;Somekawa S;Uemura S;Matsumoto M;Fujimura Y;Kimura Y;Tabata Y;Saito Y
• 通讯作者: Saito Y