New therapeutic strategy targeting thrombospondin-1 in pulmonary fibrosis
New therapeutic strategy targeting thrombospondin-1 in pulmonary fibrosis
批准号:
19790564
负责人:
ISHII Hiroshi
金额:
$2.04万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
点击翻译按钮获取中文摘要
英文摘要
間質性肺炎群と健常人の血清および気管支肺胞洗浄液を用いてTSP-1濃度をELISA法にて測定した。血清TSP-1濃度は間質性肺炎群で高値を呈し、VEGF濃度と相関しており、本疾患の病態におけるTSP-1の重要性が示された。免疫組織化学的検討では再生肺胞上皮細胞および肺胞マクロファージの重要性が示唆された。TSP-1に対するsiRNA(short interfering RNA)を数種類作製し、気道上皮細胞を用いた実験において、一つのsiRNAで良好な抑制効果がみられるようになった。肺線維症動物モデルにおける気道へのsiRNA-TSP-1投与方法を思案しながら、抑制実験にとりかかっている。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
特発性間質性肺炎におけるthrombospondin-1の発現
特发性间质性肺炎中血小板反应蛋白-1的表达
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Ishii H, Iwata A, et. al., 吉川 真弘, 石井寛, 吉川真弘, 石井寛]
通讯作者:
石井寛
High serum levels of thrombospondin-1 in patients with interstitial pneumonia
间质性肺炎患者血清血小板反应蛋白-1水平升高
DOI:
--
发表时间:
2008
期刊:
Respiratory medicine 102
影响因子:
--
作者:
[Ide M, Ishii H, et al]
通讯作者:
et al
Desquamative interstitial pneumonia(DIP) in a patient with RA : Is DIP associated with autoimmune disorders?
RA 患者发生脱屑性间质性肺炎 (DIP):DIP 与自身免疫性疾病相关吗?
DOI:
--
发表时间:
2009
期刊:
Internal Medicine 48
影响因子:
--
作者:
[Ishii H, Iwata A, et al]
通讯作者:
et al
Increased expression of thrombospondin-1 in patients with interstitial pneumonias
间质性肺炎患者血小板反应蛋白-1表达增加
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Iwata A, Ishii H, et. al.]
通讯作者:
et. al.
Desquamative interstitial pneumonia (DIP) occurred in a patient with RA : Is DIP associated with autoimmune disorders?
RA 患者发生脱屑性间质性肺炎 (DIP):DIP 与自身免疫性疾病相关吗?
DOI:
--
发表时间:
2009
期刊:
Intemal Medicine 48
影响因子:
--
作者:
[Ishii H, Iwata A, et.al.]
通讯作者:
et.al.
共 6 条
A Study on Reflective Development of Mathematics Lesson Study in Developing Country
-
批准号:16K17432
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.66万
-
财政年份:2016
-
负责人:ISHII Hiroshi
-
依托单位:
A study on practical network construction in emergency
-
批准号:26420372
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2014
-
负责人:ISHII Hiroshi
-
依托单位:
Functions of adoptive immune system after injury of the central nervous system and immunomodulatory treatment
-
批准号:24890113
-
项目类别:Grant-in-Aid for Research Activity Start-up
-
资助金额:$1.91万
-
财政年份:2012
-
负责人:ISHII Hiroshi
-
依托单位:
A network analysis of plant-pollinator interactions in alpine ecosystems in japan.
-
批准号:23770017
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.91万
-
财政年份:2011
-
负责人:ISHII Hiroshi
-
依托单位:
Elucidation of pollination network property by using the invasion event of Bombus terrestris
-
批准号:20770013
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.41万
-
财政年份:2008
-
负责人:ISHII Hiroshi
-
依托单位:
Multiple information sources and MDC based video information discovery and transfer system
-
批准号:19500064
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2007
-
负责人:ISHII Hiroshi
-
依托单位:
Integrated Study on the Methods of Overseas Scientific Research and Fieldwork
-
批准号:13371005
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$27.37万
-
财政年份:2001
-
负责人:ISHII Hiroshi
-
依托单位:
The investigation for the conservation of the Fagus crenata forest in southern limit of distribution area
-
批准号:10660151
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:1998
-
负责人:ISHII Hiroshi
-
依托单位:
Integrated Research Study on International Scientific Research
-
批准号:10041008
-
项目类别:Grant-in-Aid for Scientific Research (A).
-
资助金额:$19.71万
-
财政年份:1998
-
负责人:ISHII Hiroshi
-
依托单位:
Forest Damage by the 13th Typhoon in 1993 and Forest Management-In case of Oosumi Peninsula of Kagoshima Prefecture-
-
批准号:06660194
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1994
-
负责人:ISHII Hiroshi
-
依托单位:
Investigation to clarify a mechanism of anomalous uplift on the Izu peninsula
-
批准号:03452056
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$1.79万
-
财政年份:1991
-
负责人:ISHII Hiroshi
-
依托单位:
Research of strain field of the Japanese Islands using GPS
-
批准号:02302026
-
项目类别:Grant-in-Aid for Co-operative Research (A)
-
资助金额:$8.38万
-
财政年份:1990
-
负责人:ISHII Hiroshi
-
依托单位:
Study on development of a small three components borehole strain meter
-
批准号:61840011
-
项目类别:Grant-in-Aid for Developmental Scientific Research
-
资助金额:$2.75万
-
财政年份:1986
-
负责人:ISHII Hiroshi
-
依托单位:
国内基金
海外基金
CD47和thrombospondin-1调节糖尿病肾病代谢性炎症的作用和机制
-
批准号:82330020
-
项目类别:重点项目
-
资助金额:220万元
-
批准年份:2023
-
负责人:侯凡凡
-
依托单位:
Thrombospondin-1抑制ADSCs构建组织工程化软骨骨化的相关研究
-
批准号:81401611
-
项目类别:青年科学基金项目
-
资助金额:23.0万元
-
批准年份:2014
-
负责人:谢爱国
-
依托单位: