Positron emission tomographic demonstration of myocardial oxidative metabolism Effects of therapy on, oxidative stress, and cardiac function in Patients With Congestive Heart Failure.

正电子发射断层扫描显示心肌氧化代谢治疗对充血性心力衰竭患者氧化应激和心功能的影响。

• 批准号: 19790877
• 负责人: SHINOMIYA Kaori
• 金额: $ 2.44万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790877/
• 关键词: 酸化ストレス; 心不全; PET

In this study, to demonstrate the excess of oxidative stress in chronic heart failure patients, We also examine the effect of Beta blockers and statins, on cardiac metabolism by the C11-acetate positron emission tomography(PET). Enrolled in this study were 21 patients with chronic heart failure. All patients underwent β-blockers treatment and C11-acetate PET. The oxygen consumption was measured by the monoexponential clearance rate of 11C-acetate (Kmono) for before and after treatment. Cardiac efficiency (CE) was determined using the concept of work metabolic index (WMI). WMI was calculated as WMI=(stroke volume index) ×(systolic blood pressure)× (heart rate)/Kmono. The patients were divided into two groups: improved EF and deteriorated EF by treatment. No significant differences were observed in characteristics at baseline. The ratio of ischemic cardiomyopathy and the frequency of statins or β-blockers,did not change. Serum levels of IL-6, TNF-a and sVCAM-1 were increased in the deteriorated group. Furthermore, no significant changes were in this study.

在这项研究中，为了证明慢性心力衰竭患者的氧化应激过度，我们还通过C11-乙酸正电子发射断层扫描（PET）检查了β受体阻滞剂和他汀类药物对心脏代谢的影响。本研究入组了21例慢性心力衰竭患者。所有患者均接受了β受体阻滞剂治疗和C11-乙酸PET。采用11 C-醋酸盐（Kmono）单指数清除率测定治疗前后的氧耗量。心脏效率（CE）采用功代谢指数（WMD）的概念来确定。心搏量指数计算公式为心搏量指数×收缩压×心率/Kmono。将患者分为EF改善组和EF恶化组。基线时未观察到特征的显著差异。缺血性心肌病的比例和他汀类药物或β受体阻滞剂的使用频率没有变化。恶化组血清IL-6、TNF-α和sVCAM-1水平升高。此外，本研究中未发生显著变化。

项目成果

Acute improvement of cardiac efficiency measured by 11C-acetate PET after cardiac resynchronization therapy and clinical outcome

• DOI: 10.1007/s10554-009-9549-8
• 发表时间: 2010-03
• 期刊: The International Journal of Cardiovascular Imaging
• 作者: Kenji Kitaizumi;K. Yukiiri;H. Masugata;H. Takinami;Y. Iwado;T. Noma;N. Hosomi;K. Ohmori;S. Senda;M. Kohno

Myocardial scintigraphy and positron emission tomography.

心肌闪烁扫描和正电子发射断层扫描。

• 发表时间: 2007
• 期刊: Nippon Rinsho. 65Suppl4
• 作者: Yukiiri K;Takinami H;Shinomiya K;Kono M;Iwado Y
• 通讯作者: Iwado Y

Relationship between Myocardial Flow Reserve by Oxygen-15 Water Positron Emission Tomography in the Subacute Phase of Myocardial Infarction and Left Ventricular Remodeling in the Chronic Phase

心肌梗死亚急性期氧15水正电子发射断层扫描心肌血流储备与慢性期左心室重构的关系

• DOI: 10.1291/hypres.31.1307
• 发表时间: 2008
• 期刊: Hypertension Research
• 影响因子: 5.4
• 作者: Minako Ohara;K. Yukiiri;H. Masugata;Y. Iwado;H. Takinami;Y. Nishiyama;M. Ohkawa;S. Senda;K. Ohmori;M. Kohno
• 通讯作者: M. Kohno

Positron emission tomographic demonstration of myocardial oxidative metabolism in a case of left ventricular restoration after cardiac resynchronization therapy.

心脏再同步治疗后左心室恢复一例心肌氧化代谢的正电子发射断层扫描显示。

• 发表时间: 2008
• 期刊: Circulation Journal 72(11)
• 作者: Kitaizumi K;Yukiiri K;Masugata H;Shinomiya K;Ohara M;Takinami H;Iwado Y;Yoshida J;Noma T;Ohmori K;Yamashita Y;Horii T;Senda S;Kohno M
• 通讯作者: Kohno M