Positron emission tomographic demonstration of myocardial oxidative metabolism Effects of therapy on, oxidative stress, and cardiac function in Patients With Congestive Heart Failure.

在这项研究中，为了证明慢性心力衰竭患者的氧化应激过度，我们还通过C11-乙酸正电子发射断层扫描（PET）检查了β受体阻滞剂和他汀类药物对心脏代谢的影响。本研究入组了21例慢性心力衰竭患者。所有患者均接受了β受体阻滞剂治疗和C11-乙酸PET。采用11 C-醋酸盐（Kmono）单指数清除率测定治疗前后的氧耗量。心脏效率（CE）采用功代谢指数（WMD）的概念来确定。心搏量指数计算公式为心搏量指数×收缩压×心率/Kmono。将患者分为EF改善组和EF恶化组。基线时未观察到特征的显著差异。缺血性心肌病的比例和他汀类药物或β受体阻滞剂的使用频率没有变化。恶化组血清IL-6、TNF-α和sVCAM-1水平升高。此外，本研究中未发生显著变化。

In this study, to demonstrate the excess of oxidative stress in chronic heart failure patients, We also examine the effect of Beta blockers and statins, on cardiac metabolism by the C11-acetate positron emission tomography(PET). Enrolled in this study were 21 patients with chronic heart failure. All patients underwent β-blockers treatment and C11-acetate PET. The oxygen consumption was measured by the monoexponential clearance rate of 11C-acetate (Kmono) for before and after treatment. Cardiac efficiency (CE) was determined using the concept of work metabolic index (WMI). WMI was calculated as WMI=(stroke volume index) ×(systolic blood pressure)× (heart rate)/Kmono. The patients were divided into two groups: improved EF and deteriorated EF by treatment. No significant differences were observed in characteristics at baseline. The ratio of ischemic cardiomyopathy and the frequency of statins or β-blockers,did not change. Serum levels of IL-6, TNF-a and sVCAM-1 were increased in the deteriorated group. Furthermore, no significant changes were in this study.