Islet transplantation by gastric submucosal-injection method using Immortalizing islet cells transferred telomerase gene

使用转移端粒酶基因的永生化胰岛细胞通过胃粘膜下注射法进行胰岛移植

• 批准号: 19790921
• 负责人: SUDO Takeshi
• 金额: $ 2.32万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790921/
• 关键词: 膵島移植; 胃粘膜下注入法; テロメラーゼ; エダラボン; アポトーシス

糖尿病に対する根本的治療である膵島移植の一般化のためには移植効率の向上が必要である.移植膵島の生着率向上のための胃粘膜下注入法の確立と生着膵島の長期機能向上のためのテロメラーゼ遺伝子導入による膵島不死化について研究した.研究の課程で膵島移植効率を向上する生着促進剤を発見した.ラット膵島移植において移植後急性期のエダラボン投与は移植膵島のアポトーシスを抑制して生着促進し、移植後膵島機能を向上した.

The basic treatment of diabetes mellitus is the generalization of diabetes mellitus and the improvement of diabetes mellitus transplantation rate. The establishment of the submucosal injection method for the growth rate of the transplanted islets and the long-term function of the transplanted islets. Research on the curriculum of the island transplant rate to promote the development of In the acute stage after transplantation, the function of the transplanted islets is promoted and the function of the transplanted islets is improved.

项目成果

Specific antibiotic prophylaxis based on bile cultures is required to prevent postoperative infectious complications in pancreatoduodenectomy patients who have undergone preoperative biliary drainage

• DOI: 10.1007/s00268-007-9210-4
• 发表时间: 2007-11-01
• 期刊: WORLD JOURNAL OF SURGERY
• 影响因子: 2.6
• 作者: Sudo, Takeshi;Murakami, Yoshiaki;Sueda, Taijiro
• 通讯作者: Sueda, Taijiro

Detection of human telomerase reverse transcriptase (hTERT) expression in tissue and pancreatic juice from pancreatic cancer

• DOI: 10.1016/j.surg.2007.07.042
• 发表时间: 2008-01-01
• 期刊: SURGERY
• 影响因子: 3.8
• 作者: Hashimoto, Yasushi;Murakami, Yoshiaki;Hiyama, Eiso
• 通讯作者: Hiyama, Eiso

Long-term pancreatic endocrine function following pancreatoduodenectomy with pancreaticogastrostomy

• DOI: 10.1002/jso.21004
• 发表时间: 2008-05-01
• 期刊: JOURNAL OF SURGICAL ONCOLOGY
• 影响因子: 2.5
• 作者: Murakami, Yoshiaki;Uemura, Kenichiro;Sueda, Taijiro
• 通讯作者: Sueda, Taijiro

An antecolic Roux-en Y type reconstruction decreased delayed gastric emptying after pylorus-preserving pancreatoduodenectomy

• DOI: 10.1007/s11605-008-0483-1
• 发表时间: 2008-06-01
• 期刊: JOURNAL OF GASTROINTESTINAL SURGERY
• 影响因子: 3.2
• 作者: Murakami, Yoshiaki;Uemura, Kenichiro;Sueda, Taijiro
• 通讯作者: Sueda, Taijiro

Adjuvant gemcitabine plus S-1 chemotherapy after surgical resection for pancreatic adenocarcinoma

胰腺癌手术切除后吉西他滨联合 S-1 辅助化疗

• 发表时间: 2008
• 期刊: Am J Surg 195(6)
• 作者: Murakami Y;Uemura K;Sudo T;Hayashidani Y;Hashimoto Y;Nakagawa N;Ohge H;Sueda T
• 通讯作者: Sueda T