Role of heparan sulfate proteoglycan in joint development
Role of heparan sulfate proteoglycan in joint development
批准号:
19791036
负责人:
MATSUMOTO Yoshihiro
金额:
$2.3万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010
中文摘要
为阐明关节疾病的发病机制,探讨硫酸肝素(HS)在关节发育中的作用。细胞表面HS的缺失导致骨形态发生蛋白的弥漫性分布和间质凝聚的异常形成,而间质凝聚对关节发育至关重要。这些结果清楚地表明HS在关节发育中的基本和细胞生物学作用。
英文摘要
To elucidate the pathogenesis of joint diseases, the roles of heparan sulfate (HS) in the joint development was investigated. Loss of HS in the cell surface causd the diffuse distribution of bone morphogenetic protein and the abnormal formation of mesenchymal condensation that was critical for the joint development. These results clearly indicated the essential and cell biological roles of HS in the joint development.
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Roles of heparan sulfate in mammalian brain development current views based on the findings from Ext1 conditional knockout studies.
基于 Ext1 条件敲除研究结果的硫酸乙酰肝素在哺乳动物大脑发育中的作用的当前观点。
DOI:
--
发表时间:
2010
期刊:
Prog Mol Biol Transl Sci. 93
影响因子:
--
作者:
[Yamaguchi Y, Inatani M, Matsumoto Y, Ogawa J, Irie F.]
通讯作者:
Irie F.
Essential role of heparan sulfate on axon guidance in developmental spinal cord
硫酸乙酰肝素对发育性脊髓轴突引导的重要作用
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Y Matsumoto, et al.]
通讯作者:
et al.
平成21年度日本対がん協会福岡県支部がん研究助成金
2009年 日本癌症协会福冈县分会癌症研究补助金
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1523/jneurosci.0700-07.2007
发表时间:
2007-04-18
期刊:
JOURNAL OF NEUROSCIENCE
影响因子:
5.3
作者:
[Matsumoto, Yoshihiro, Irie, Fumitoshi, Yamaguchi, Yu]
通讯作者:
Yamaguchi, Yu
Conditional ablation of the heparan sulfate-synthesizing enzyme Extlleads to dysregulation of bone morphogenic protein signaling and severe skeletal defects.
有条件地消除硫酸乙酰肝素合成酶 Extl 会导致骨形态发生蛋白信号传导失调和严重的骨骼缺陷。
DOI:
--
发表时间:
2010
期刊:
J Biol Chem.
影响因子:
--
作者:
[Matsumoto Y., et al.]
通讯作者:
et al.
共 18 条
Development of new treatment for chondrosarcoma by targeting sarcoma stem cells
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批准号:23592192
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2011
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负责人:MATSUMOTO Yoshihiro
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依托单位:
Spectroscopy of Organic Molecule/Ferromagnetic Metal Interface for Highly Efficient Room Temperature Spin injection into Graphene
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批准号:22740206
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2010
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负责人:MATSUMOTO Yoshihiro
-
依托单位:
Development of a CASE Repository Integrating Software Processes and Products
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批准号:05558037
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$5.89万
-
财政年份:1993
-
负责人:MATSUMOTO Yoshihiro
-
依托单位:
海外基金