Influence of abnormal body temperature on expression of mucin in the respiratory tract under the artificial respiration Hyperthermia vs hypothermia-

人工呼吸条件下体温异常对呼吸道粘蛋白表达的影响

• 批准号: 19791072
• 负责人: HASEGAWA Akira
• 金额: $ 2.38万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791072/
• 关键词: 人工呼吸; 体温; 温熱ストレス; 熱ショック蛋白質; ムチン; 集中治療

Inflammation lets mucin in the respiratory duct increase,but does not understand whether expression of mucin comes under what kind of influence by abnormal body temperature. First of all, I clarified relations of inflammation and body temperature. It is known that we have cytoprotective protection effect for aggression in heat shock protein (HSP). I made a rat endotoxin shock model and examined protection effect when I induced HSP. As s result, it was recognized that HSP was induced by adding heat stress (42℃15minutes), and inhibited inflammation significantly, and improved the survival rate. I will push forward study about body temperature and relations with expression of mucin more in future.

炎症使呼吸道中的粘蛋白增加，但不清楚粘蛋白的表达是否受到异常体温的影响。首先，我阐明了炎症和体温的关系。热休克蛋白（HSP）对攻击性机体具有细胞保护作用。本实验建立了大鼠内毒素休克模型，观察了HSP对内毒素休克大鼠的保护作用。结果表明，热应激（42℃ 15min）诱导HSP表达，并能显著抑制炎症反应，提高存活率。今后将进一步推进体温与粘蛋白表达关系的研究。

项目成果

敗血症の致死的メディエーターであるHMGB1に対するHSPの効果

HSP 对败血症致命介质 HMGB1 的影响

• 发表时间: 2008
• 作者: 長谷川輝;岩坂日出男;萩原聡;野口隆之;長谷川輝;長谷川輝
• 通讯作者: 長谷川輝

Relationship Between HMGB1 and Tissue Protective Effects of HSP72 in a LPS-Induced Systemic Inflammation Model

• DOI: 10.1016/j.jss.2009.10.015
• 发表时间: 2011-07-01
• 期刊: JOURNAL OF SURGICAL RESEARCH
• 影响因子: 2.2
• 作者: Hasegawa, Akira;Iwasaka, Hideo;Noguchi, Takayuki
• 通讯作者: Noguchi, Takayuki