Influence on prostate cancer of bone marrow stem cell (pre-adipocytes) :Comprehensive analysis of the signaling pathways

点击翻译按钮获取中文摘要

We examined signaling pathways with human prostate cancer cell line and pre-adipocytes .Cancer cells were co-cultured with the isolated mature adipocytes in 3-D collagen gel matrix culture. In LNCaP, humoral factors and cell to cell contaction are necessary for proliferation. In PC-3, cell to cell contaction is necessary for differentiation. In DU145, humoral factors and cell to cell contaction are necessary for proliferation and differentiation. As a result of cDNA microarray, Prostate-specific expression PSGR2 and integrin significantly increased.