A Study about the Protection of Functional Deterioration of Deglutition Decline with the Aging by the Hypopharyngeal Constrictor Muscle dosage of IGF-1

下咽缩肌IGF-1剂量对衰老吞咽衰退功能退化的保护作用研究

• 批准号: 19791211
• 负责人: TAGUCHI Aki
• 金额: $ 2.34万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791211/
• 关键词: 下咽頭収縮筋; 加齢; 神経栄養因子; 嚥下機能予防低下; 嚥下機能低下予防

We studied about the protection of functional deterioration of deglutition decline by IGF-1. In the present study, aging effects in the subneural apparatus (SNA) were histologically investigated in the inferior pharyngeal muscle of a rat using scanning electron microscopy. In the cricopharyngeal muscle, the depression type of the primary synaptic clefts were 63.4%, while the IGF-1 dosage group were 60%. There was more it than aging group, and an unripe nervous system bottom device appeared in the group of IGF-1 dosage aging in comparison with the aging group. In addition, about 27% were able to observe the nervous system bottom device that a secondary synapse was observed outward from the ditch of the primary synapse.

我们研究了IGF-1对吞咽功能下降的保护作用。在本研究中，使用扫描电子显微镜对大鼠下咽肌的神经下装置（SNA）的衰老影响进行了组织学研究。环咽肌中，初级突触间隙凹陷型为63.4%，而IGF-1剂量组为60%。与衰老组相比，IGF-1剂量衰老组的神经系统底器较衰老组多，且与衰老组相比，出现了未成熟的神经系统底器。此外，约27%的人能够观察到从初级突触沟向外观察到次级突触的神经系统底部装置。

项目成果

A complex muscle fiber network in the cridothyroid muscle: a scanning electron microscopic study.

环甲肌中复杂的肌肉纤维网络：扫描电子显微镜研究。

• 发表时间: 2007
• 期刊: Laryngoscope 117
• 作者: Hyodo M;Taguchi A;Yamagata T;Desaki J
• 通讯作者: Desaki J