Analysis of the biological role of SCCA1 protein in head and neck cancer cells.

SCCA1蛋白在头颈癌细胞中的生物学作用分析。

• 批准号: 19791212
• 负责人: YASUMATSU Ryuji
• 金额: $ 2.32万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791212/
• 关键词: SCC抗原; 頭頸部癌; プロテアーゼインヒビター; protease inhibitor; 腫瘍マーカー; SCC 抗原

SCCA1 is the member of the clade B serpin and is an inhibitor of cysteine proteases, cathepsin (cat) K, L, and S. However its physiologic function in HNSCC is unknown. Recent studies demonstrated that the expression of SCCA1 was increasing in HNSCC. We hypothesized that altered expression of SCCA1 in HNSCC could contribute to block the protease activity and investigated whether SCCA1 could make the complex with the new protease in HNSCC.In this study, however, we could not find any new proteases which could make the complex with SCCA1 protein. Further examination is necessary to conclude that SCCA1 can block the new protease in patients with HNSCC.

Sca 1属于B分支丝蛋白，是半胱氨酸蛋白酶、组织蛋白(CAT)K、L和S的抑制剂，但其在人喉鳞状细胞癌中的生理功能尚不清楚。最近的研究表明，SCCA1在HNSCC中的表达增加。我们推测SCCA1在HNSCC中的表达变化可能有助于阻断该蛋白的活性，并研究了SCCA1在HNSCC中是否能与新的蛋白水解酶形成复合体。然而，在本研究中，我们没有发现任何新的酶与SCCA1蛋白形成复合体。需要进一步的检查才能得出结论，SCCA1可以阻断HNSCC患者中的新的蛋白酶。

项目成果

The role of Dihydropyrimidine dehydrogenase expression in resistance to 5-Fluorouracil in head and neck souamous cell carcinoma cells

二氢嘧啶脱氢酶表达在头颈鳞状细胞癌细胞5-氟尿嘧啶耐药中的作用

• 发表时间: 2008
• 作者: Takenori Miyashita;Kosuke Akiyama;Ryuhei Inamoto;Terushige Mori;Nozomu Mori;Yasumatsu R
• 通讯作者: Yasumatsu R

A Novel SERPINB11 expression in HNSCC

HNSCC 中新的 SERPINB11 表达

• 发表时间: 2007
• 作者: Yasumatsu;R;et. al.
• 通讯作者: et. al.

頭頸部扁平上皮癌におけるDihydropyrimidine dehydrogenase (DPD)発現の意義

二氢嘧啶脱氢酶（DPD）在头颈部鳞状细胞癌中表达的意义

• 作者: 安松隆治;中島寅彦;伊藤彩;小宗静男
• 通讯作者: 小宗静男

鼻アレルギー疾患の最近の知見

鼻过敏性疾病的最新发现

• 作者: Inamoto Ryuhei;Miyashita Takenori;Akiyama Kosuke;Mori Terushige;Mori Nozomu;安松隆治
• 通讯作者: 安松隆治

The role of dihydropyrimidine dehydrogenase expression in resistance to 5-Fluorouracil in head and neck sauamous cell carcinoma cells

二氢嘧啶脱氢酶表达在头颈鳞癌细胞5-氟尿嘧啶耐药中的作用

• 发表时间: 2009
• 期刊: Oral oncology 45
• 作者: Yasumatsu R;et.al.
• 通讯作者: et.al.