The elucidation of the mechanisms of dexamethasone-regulated osteoblast differentiation
The elucidation of the mechanisms of dexamethasone-regulated osteoblast differentiation
批准号:
19791351
负责人:
MIKAMI Yoshikazu
金额:
$2.47万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
In this study, we investigated the mechanisms by which dexamethasone (Dex) affects osteoblast differentiation. This study demonstrated that Dex regulated osteoblast differentiation on the cell-differentiation stage dependent manner, and that MAP kinase and Jak-STAT signaling pathway were involved in the mechanisms for the Dex-regulated osteoblast differentiation.
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A new synthetic compound, SST-EDI-1 inhibits osteoblast differentiation by down-regulating Osterix expression.
SST-EDI-1 是一种新的合成化合物,通过下调 Osterix 表达来抑制成骨细胞分化。
DOI:
--
发表时间:
2009
期刊:
The Journal of Biochemistry. 145
影响因子:
--
作者:
[Mikami Y, Somei M, Takagi M.]
通讯作者:
Takagi M.
DOI:
10.1016/j.bbrc.2007.07.192
发表时间:
2007-10-19
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Mikami, Yoshikazu, Omoteyama, Kazuki, Takagi, Minoru]
通讯作者:
Takagi, Minoru
DOI:
10.1016/j.cellbi.2007.08.033
发表时间:
2008-02-01
期刊:
CELL BIOLOGY INTERNATIONAL
影响因子:
3.9
作者:
[Mikami, Yoshikazu, Takahashi, Tomihisa, Takagi, Minoru]
通讯作者:
Takagi, Minoru
ROS17/2.8細胞における石灰化と骨芽細胞分化関連因子の発現に対するデキサメサゾンの影響
地塞米松对ROS17/2.8细胞矿化及成骨细胞分化相关因子表达的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Mikami Y, Omoteyama Y, Takagi M., Yoshikazu Mikami, Yoshikazu Mikami, 三上 剛和]
通讯作者:
三上 剛和
A tryptamine derivative, SST-EDI-1, inhibits apoptosis and stimulates mineralization in osteoblasts.
色胺衍生物 SST-EDI-1 可抑制成骨细胞凋亡并刺激矿化。
DOI:
--
发表时间:
2009
期刊:
Endocrine Journal. 56
影响因子:
--
作者:
[Mikami Y, Somei M, Takagi M.]
通讯作者:
Takagi M.
共 6 条
Establishment of a method to promote osteoblast differentiation using tryptophan derivatives and Dex, and elucidation of the mechanisms of them
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批准号:22791778
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.5万
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财政年份:2010
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负责人:MIKAMI Yoshikazu
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依托单位:
海外基金