A genome-wide association study of mandibular prognathism using pooled DNA typing

使用汇总 DNA 分型进行下颌前突的全基因组关联研究

• 批准号: 19791561
• 负责人: KAJII Takashi
• 金额: $ 1.86万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791561/
• 关键词: 歯科矯正学; 基礎ゲノム科学; ヒトゲノムDNA; ゲノムワイド遺伝的相関解析; pooled DNAタイピング; 骨格性下顎前突症; pooled DNAタピング

The pooled DNA of 140 of mandibular prognathism (case) group and that of 180 of healthy (control) group were prepared. We conducted a genome-wide association study of mandibular prognathism using micro-satellite markers and the pooled DNA. The first screening of genome-wide association study focused 750 of loci associated with mandibular prognathism from 30,000 of total loci.

制备下颌骨发育不良组（病例组）140例和健康对照组（对照组）180例的混合DNA。我们使用微卫星标记和合并的DNA进行了下颌骨无颌症的全基因组关联研究。全基因组关联研究的第一次筛选集中在30，000个总位点中的750个与下颌骨无颌相关的位点。

项目成果

Relationship between degree of malocclusion and occlusal interference in mice that spontaneously develop anterior transverse crossbite

自发性前牙横牙合小鼠错牙合程度与咬合干扰的关系

• 发表时间: 2010
• 期刊: American Journal of Orthodontics and Dentofacial Orthopedics 138(in press)
• 作者: Tsukamoto Y;Kajii TS;Sugawara-Kato Y;Hirabayashi Y;Fujimori O;Iida J
• 通讯作者: Iida J

Growth and development of the cranial base of BALB/c-bm/bm mouse that spontaneously induces anterior transverse crossbite: Histological study

BALB/c-bm/bm 小鼠颅底的生长和发育自发诱导前横牙反：组织学研究

• 发表时间: 2008
• 期刊: American Journal of Orthodontics and Dentofacial Orthopedics 133(In press)
• 作者: Tsukamoto Y;Kajii TS;Oonshi Y;Sugawara-Kato Y;Hirabayashi Y;Iida J
• 通讯作者: Iida J

ゲノムワイド関連解析を用いた顎顔面変形症の発症予測システム構築.

使用全基因组关联分析构建预测颌面畸形发病的系统。

• 发表时间: 2009
• 作者: Tsukamoto Y;Kajii TS;Oonshi Y;Sugawara-Kato Y;Hirabayashi Y;Iida J;小澤重幸;梶井貴史;梶井貴史;梶井貴史
• 通讯作者: 梶井貴史

Growth and development of the cranial base of BALB/c-bm/bm mouse that spontaneously induces anterior transverse crossbite: Histological study.

BALB/c-bm/bm 小鼠颅底的生长和发育自发诱导前横牙反：组织学研究。

• 发表时间: 2008
• 期刊: American Journal of Orthodontics and Dentofacial Orthopedics 134
• 作者: Tsukamoto Y;Kajii TS;Oonshi Y;Sugawara-Kato Y;Hirabayashi Y;Iida J
• 通讯作者: Iida J

不正咬合自然発症マウスの顎顔面形態-マイクロCTを用いて-

自发性错牙合小鼠的颌面形态 - 使用显微 CT -

• 发表时间: 2009
• 作者: Tsukamoto Y;Kajii TS;Oonshi Y;Sugawara-Kato Y;Hirabayashi Y;Iida J;小澤重幸;梶井貴史;梶井貴史
• 通讯作者: 梶井貴史