A genome-wide association study for maxilla-facial deformity using pooled DNA typing

使用汇总 DNA 分型进行上颌面部畸形的全基因组关联研究

• 批准号: 22592272
• 负责人: KAJII Takashi
• 金额: $ 2.91万
• 依托单位: Fukuoka Dental College (2012)Hokkaido University (2010-2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592272/
• 关键词: 歯科矯正学; 基礎ゲノム科学; ゲノムワイド関連解析; pooled DNA; ゲノム関連解析; 顎顔面変形症; Dooled DNA

At first, we conducted second screening of a genome-wideassociation study of mandibular prognathism. Over 10 of microsatellite markers showedsignificant association with mandibular prognathism from the result of second screening.Next we conducted individual typing (third screening) of a genome-wide association studyof mandibular prognathism. It was suggested that 1p22.3, 1q32.2, and 15q22.2 are candidateloci for mandibular prognathism.

首先，我们进行了第二次筛选的全基因组关联研究下颌骨肥大。第二次筛选的结果显示，有10多个微卫星标记与下颌骨多突症有显著关联。提示1p22.3、1q32.2和15q22.2是下颌骨多突症的候选基因位点。

项目成果

Congenital and Postnatal Factors Inducing Malocclusions in Japanese Unilateral Cleft Lip and Palate Patients-Determination Using Logistic Regression Analysis

• DOI: 10.1597/11-150
• 发表时间: 2013-07-01
• 期刊: CLEFT PALATE-CRANIOFACIAL JOURNAL
• 作者: Kajii, Takashi S.;Alam, Mohammad K.;Iida, Junichiro
• 通讯作者: Iida, Junichiro

Congenital and postnatal factors affecting malocclusions of Japanese unilateral cleft lip and palate patients-Using multivariate statistical analysis-

影响日本单侧唇腭裂患者咬合不正的先天性和后天因素-采用多因素统计分析-

• 发表时间: 2011
• 作者: Kajii TS;Sato Y;Iida J
• 通讯作者: Iida J

Congenital and postnatal factors affecting malocclusions of Japanese unilateral cleft lip and palate patients Using multivariate statistical analysis-.

影响日本单侧唇腭裂患者咬合不正的先天性和后天因素的多因素统计分析。

• 发表时间: 2011
• 作者: Kajii TS;Sato Y;Iida J
• 通讯作者: Iida J

Morphological evaluation of cranial and maxillary shape differences of the brachymorphic mouse with spontaneous malocclusion using three-dimensional micro-computed tomography

三维显微计算机断层扫描对自发性错牙合短形小鼠颅骨和上颌骨形状差异的形态学评估

• DOI: 10.1111/j.1601-6343.2011.01513.x
• 发表时间: 2011
• 期刊: Orthodontics & Craniofacial Research
• 影响因子: 3.1
• 作者: F Saito;et al.
• 通讯作者: et al.

成長期の骨格性下顎前突症における下顎骨の過大な成長の予測-形態学的研究とゲノム解析を用いて-.

使用形态学研究和基因组分析预测生长过程中骨骼下颌前突的过度下颌生长。

• 发表时间: 2012
• 期刊: 福岡歯科大学学会雑誌
• 作者: Kajii TS;Alam MK;Mikoya T;Oyama A,Koshikawa-Matsuno M;Sugawara-Kato Y;Sato Y;Iida J;Kohnomi S;Kishimoto N.;Takao Kasahara;野村真有美;梶井貴史
• 通讯作者: 梶井貴史