A Research of pleasant sounds those bring human relaxation, based on the neural mechanism of instinct.

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I explored the attractive sounds for human, and physical effects of those attractive auditory stimulations were examined in both of the human and the mouse. Human examinees were exposed a sequence of auditory stimulation which are composed of several kinds of sound (ex. watch, wavelets, music) and white noise. Some of these sounds were judged as attractive by the examinees in an interview study. A near infrared spectroscopic study revealed that the activity of the frontal cortex were stable during the attractive sound stimulation. I kept mice in a box that controlled sound and light condition. The mice were exposed twelve hours (20:00-8:00) of the attractive sound stimulation for a week. After the sound exposing period, the mice were sacrificed and monoamine concentration in their brain was measured by high performance liquid chromatography. Concentration of serotonin in the frontal brain region of the sound exposed mice was higher than the mice kept in silent. These results suggest that serotonergic system can be involved in the attractive physical effects of sounds.