Design of simulated moving bed chromatography based on asynchronous shifts

基于异步位移的模拟移动床色谱设计

• 批准号: 5362911
• 负责人: Professor Dr. Lutz Tobiska
• 金额: --
• 依托单位: Max-Planck-Institut für Dynamik komplexer technischer Systeme
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2002
• 资助国家: 德国
• 起止时间: 2001-12-31 至 2005-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5362911?language=en
• 关键词: Design; simulated; moving; bed; chromatography

In recent years continuous chromatographical processes have attained an increasing interest in the production of pure chemical components in particular in the pharmaceutical industry. Based on the true moving bed process the simulated moving bed (SMB) process with a simultaneous shift of the inlet and outlet points in a multicolumn system has been investigated and successfully implemented in practice. However, the traditional SMB process exhibits several disadvantages which could be avoided by a more flexible regime of shifting the inlet and outlet positions at different moments during the time intervall. To find an optimal process regime for the SMB with asynchronous shift, a detailed mathematical model based on the numerical solution of the underlying partial differential equations and the application of advanced methods of discrete mathematics and integer programming is needed. The mathematical model and solution strategies will be verified by performing selected experiments using a partly available lab scale SMB unit.

近年来，连续色谱法在纯化学组分的生产中获得了越来越多的关注，特别是在制药工业中。在真实移动床工艺的基础上，研究了多柱系统进出口点同时移动的模拟移动床工艺，并在实践中成功实施。然而，传统的SMB工艺表现出几个缺点，这些缺点可以通过在时间间隔期间的不同时刻改变入口和出口位置的更灵活的方案来避免。为了找到一个最佳的工艺制度的SMB与异步转移，一个详细的数学模型的基础上的数值解的基本偏微分方程和应用先进的离散数学和整数规划的方法是必要的。将通过使用部分可用的实验室规模SMB装置进行选定的实验来验证数学模型和解决方案策略。