Elucidation of pathophysiological roles of oxidized high-density lipoprotein aimed at finding new diagnosis and treatment for vascular diseases

在动脉粥样硬化斑块中检测到的浓度的炎性标志物治疗对血管细胞，如内皮细胞和平滑肌细胞的存活率影响较小。在标记蛋白的结合亲和力方面，未氧化的和氧化的脂蛋白之间没有显著差异，而在标记存在的情况下，脂蛋白的氧化修饰导致标记-脂蛋白结合物增加，氧化的载脂蛋白略有下降。此外，与无炎症标志物制备的氧化型脂蛋白相比，结合物对内皮细胞的敏感性较低，提示该标志物参与了动脉粥样硬化的抑制机制。

Treatment with inflammatory markers at concentrations which are detected in atheromatous plaques less affected the viabilities of vascular cells such as endothelial cells and smooth muscle cells. In the binding affinity for the marker proteins, no significant difference was observed between un-oxidized and oxidized lipoproteins, whereas the oxidative modification of lipoprotein in the presence of the markers resulted in an increase in the maker-lipoprotein conjugates and a slight decrease in the oxidized apoprotein. In addition, the conjugates were less susceptible to endothelial cells than oxidized lipoproteins prepared without inflammatory marker, suggesting the involvement of the marker in the suppressive mechanism of atherogenesis.