Elucidation of pathophysiological roles of oxidized high-density lipoprotein aimed at finding new diagnosis and treatment for vascular diseases

用在动脉粥样硬化斑块中检测到的浓度的炎性标记物治疗对血管细胞如内皮细胞和平滑肌细胞的活力影响较小。在标记蛋白的结合亲和力，未氧化和氧化的脂蛋白之间没有显着差异，而在标记物的存在下，脂蛋白的氧化修饰导致标记物-脂蛋白缀合物的增加和氧化的载脂蛋白略有减少。此外，缀合物对内皮细胞的敏感性低于不含炎症标记物的氧化脂蛋白，表明标记物参与了动脉粥样硬化形成的抑制机制。

Treatment with inflammatory markers at concentrations which are detected in atheromatous plaques less affected the viabilities of vascular cells such as endothelial cells and smooth muscle cells. In the binding affinity for the marker proteins, no significant difference was observed between un-oxidized and oxidized lipoproteins, whereas the oxidative modification of lipoprotein in the presence of the markers resulted in an increase in the maker-lipoprotein conjugates and a slight decrease in the oxidized apoprotein. In addition, the conjugates were less susceptible to endothelial cells than oxidized lipoproteins prepared without inflammatory marker, suggesting the involvement of the marker in the suppressive mechanism of atherogenesis.