Development of metastatic breast cancer therapies with anticancer drug-loaded inorganic nanoparticles targeted to lymph nodes

靶向淋巴结的抗癌药物无机纳米粒子开发转移性乳腺癌疗法

• 批准号: 19790143
• 负责人: MURAKAMI Tatsuya
• 金额: $ 2.33万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790143/
• 关键词: ドラッグデリバリー; ナノ粒子; カーボンナノチューブ; 癌化学療法; 乳癌; リンパ節転移; 腋窩リンパ節; ドラッグキャリア

Novel drug-drug carrier complexes with a new type of nanocarbon material, carbon nanohorn (CNH), have been developed. CNH was easily loaded with an anticancer drug, doxorubicin (DXR). The complex slowly released DXR, which would contribute to enhancement of the antitumor activity. When CNH was loaded with an photosensitizer, zinc phthalocyanine (ZnPc), the complex enabled double photodynamic and photothermal cancer therapies. More importantly, CNH administered into tumor-bearing mice was able to accumulate in the adjacent axial lymph nodes, which are well known to be an organ in which breast cancer metastasis often occurs.

已经开发出具有新型纳米碳材料碳纳米角（CNH）的新型药物-药物载体复合物。 CNH 很容易装载抗癌药物阿霉素 (DXR)。该复合物缓慢释放DXR，这将有助于增强抗肿瘤活性。当 CNH 负载光敏剂酞菁锌 (ZnPc) 时，该复合物可实现双重光动力和光热癌症治疗。更重要的是，给予荷瘤小鼠的CNH能够在邻近的轴向淋巴结中积聚，而众所周知，这些淋巴结是乳腺癌经常发生转移的器官。

项目成果

生体ナノ粒子を用いたドラッグキャリア開発

使用生物纳米颗粒开发药物载体

• 发表时间: 2009
• 期刊: Drug Delivery System 24
• 作者: Shimizu;M.;Matsumoto;Y.;and Yamazaki;H;村上達也
• 通讯作者: 村上達也

Intracellular drug delivery by genetically engineered high density lipoprotein

基因工程高密度脂蛋白的细胞内药物递送

• 发表时间: 2009
• 作者: 永島里美;清水万紀子;矢野裕士;村山典恵;山崎浩史;Tatsuya Murakami
• 通讯作者: Tatsuya Murakami

抗癌剤担持水溶性カーボンナノホーンの薬理評価

抗癌药物支持的水溶性碳纳米角的药理评价

• 发表时间: 2007
• 作者: 山崎浩史;清水万紀子;永島里美;村山典恵;村上達也
• 通讯作者: 村上達也

Photoinduced Electron Transfer in Zinc Phthalocyanine Loaded on Single‐Walled Carbon Nanohorns in Aqueous Solution

• DOI: 10.1002/adma.200901256
• 发表时间: 2009-11
• 期刊: Advanced Materials
• 影响因子: 29.4
• 作者: Atula S. D. Sandanayaka;O. Ito;Minfang Zhang;Kumiko Ajima;S. Iijima;M. Yudasaka;T. Murakami;K. Tsuchida

Enhancement of in vivo anticancer effects of cicplatin by incorporation inside single-wall carbon nanohorns

通过掺入单壁碳纳米角增强环铂的体内抗癌作用

• 发表时间: 2008
• 期刊: ACS Nano 2
• 作者: Ajima;K
• 通讯作者: K