Study on the physiological role of signal adaptor DAP10 in osteoclast development
信号接头DAP10在破骨细胞发育中的生理作用研究
基本信息
- 批准号:19790203
- 负责人:
- 金额:$ 2.36万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Young Scientists (B)
- 财政年份:2007
- 资助国家:日本
- 起止时间:2007 至 2008
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DAP10遺伝子欠損マウスの解析において,DAP10遺伝子欠損マウスが加齢に伴う破骨細胞の分化障害により骨硬化を呈することを明らかにした.さらに,破骨細胞におけるDAP10会合分子の探索を行ったところ,Myeloid DAP12-associating lectin (MDL)-1を同定し, MDL-1/DAP10/DAP12の三量体を形成することを示した.このようにDAP10はMDL-1を介してDAP12と協調的にはたらき,破骨細胞分化を制御していることを明らかにした.
DAP10 gene deficiency analysis,DAP In addition, the exploration of DAP10 binding molecules in osteoclasts has been carried out, and Myeloid DAP12-associating lectin (MDL)-1 has been determined, and the triad of MDL-1/DAP10/DAP12 has been formed. DAP-10 is the only one that regulates osteoclast differentiation.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12
- DOI:10.1073/pnas.0900463106
- 发表时间:2009-03-24
- 期刊:
- 影响因子:11.1
- 作者:Inui, Masanori;Kikuchi, Yuki;Takai, Toshiyuki
- 通讯作者:Takai, Toshiyuki
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development
- DOI:10.4049/jimmunol.181.7.4742
- 发表时间:2008-10-01
- 期刊:
- 影响因子:4.4
- 作者:Mori, Yu;Tsuji, Sukenao;Takai, Toshiyuki
- 通讯作者:Takai, Toshiyuki
A novel regulatory role of gp49B on dendritic cells in T-cell priming
- DOI:10.1002/eji.200737550
- 发表时间:2008-09-01
- 期刊:
- 影响因子:5.4
- 作者:Kasai, Satoshi;Inui, Masanori;Takai, Toshiyuki
- 通讯作者:Takai, Toshiyuki
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INUI Masanori其他文献
INUI Masanori的其他文献
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{{ truncateString('INUI Masanori', 18)}}的其他基金
Functional analysis of neurite outgrowth inhibitor proteins in B cell activation
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- 批准号:
24590572 - 财政年份:2012
- 资助金额:
$ 2.36万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Chemokines as novel therapeutic targets in inflammatory arthritis
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22790388 - 财政年份:2010
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$ 2.36万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Studies on anomalous dynamic properties in supercritical metallic fluids using a high-resolution inelastic x-ray scattering technique
利用高分辨率非弹性 X 射线散射技术研究超临界金属流体的反常动力学特性
- 批准号:
20244061 - 财政年份:2008
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$ 2.36万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Bonding, Fluctuations and Dynamics in Supercritical Metallic Fluids Using Synchrotron Radiation
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- 批准号:
16340114 - 财政年份:2004
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$ 2.36万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Density fluctuations and cluster formation for conductive fluids near liquid-vapor supercritical region.
液-汽超临界区附近导电流体的密度波动和团簇形成。
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09640485 - 财政年份:1997
- 资助金额:
$ 2.36万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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