The analysis of the dendritic cells in liver is useful for the condition clarification and the earlier detection of the autoimmune hepatitis.

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We examined whether there was relationship between the proportional change of dendritic cells in the liver of model mouse and the condition of the autoimmune hepatitis. We hypothesized that these results were useful for the clarification of the early diagnostics and underlying mechanism of the autoimmune hepatitis. The plasmacytoid dendritic cells in liver decreased at early stage of liver injury. Activated conventional dendritic cells increased with the liver of the model mouse and produced a large amount of inflammatory cytokines. It explained that the intrahepatic plasmacytoid dendritic cells were necessary to prevention of liver damage. In this situation, the regulatory T cell also increased in liver of the mice. The prevention of the autoimmune hepatitis is necessary for the association between intrahepatic plasmacytoid dendritic cells and regulatory T cells. It was suggested that these findings were useful for the early diagnosis of autoimmune hepatitis and the new method of treatment in the future.