Relationship between the onset of autoimmune hepatitis and hepatic dendritic cells by gender devise.

点击翻译按钮获取中文摘要

It has been reported that autoimmune hepatitis is induced by the drastic change of sex hormone, such as pregnancy and menopause. However, its pathogenic mechanism is not well-known. In this study, we focused on the hepatic dendritic cells. We used the mouse model of autoimmune hepatitis to investigate the effect of the autologous reactivity of estrogen. As a result, it was shown that the autoimmune liver injury of the mice was inhibited by the administration of estrogen. At the same time, the number of CD274+ immature dendritic cells was increased in the liver of those autoimmune hepatitis mice. Moreover only these dendritic cells showed the elevated ability to produce IL-10. At the same time they indicated the decreased serum level of IL-12. These results suggested that the inhibitory dendritic cells, which were increased in the liver by estrogen exposure, suppressed the autoimmune liver injury.