Genetic ablation of transcription repressor Bach1 reduces neural tissue damage after spinal cord injury in mice
Genetic ablation of transcription repressor Bach1 reduces neural tissue damage after spinal cord injury in mice
批准号:
19591712
负责人:
OZAWA Hiroshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Heme oxygenase-1(HO-1)は生体内で強力な抗酸化作用を有し、酸化ストレスによる組織傷害を抑制する。本研究の結果、Bach1 KOマウスでは、損傷脊髄におけるHO-1の発現が増加し、また神経組織傷害、アポトーシスおよび運動機能障害が抑制されることが分かった。したがって、Bach1のノックアウトによってHO-1の発現が増加し、脊髄損傷後の酸化ストレスによる脊髄障害が抑制されると考えられた。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Transcription Repressor Bachl Deletion Reduces Neural Tissue Damage and Locomotor Impairment after Spinal Cord Injury in Mice
转录抑制因子 Bachl 缺失可减少小鼠脊髓损伤后的神经组织损伤和运动障碍
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[菅野晴夫, 小澤浩司]
通讯作者:
小澤浩司
Transcription Repressor Bach1 Deletion Reduces Neural Tissue Damage and Locomotor Impairment after Spinal Cord Injury in Mice
转录抑制因子 Bach1 缺失可减少小鼠脊髓损伤后的神经组织损伤和运动障碍
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[菅野晴夫, 小澤浩司]
通讯作者:
小澤浩司
DOI:
10.1089/neu.2008.0667
发表时间:
2009-01-01
期刊:
JOURNAL OF NEUROTRAUMA
影响因子:
4.2
作者:
[Kanno, Haruo, Ozawa, Hiroshi, Itoi, Eiji]
通讯作者:
Itoi, Eiji
A Study of Target Costing Ability:An Approach from Engineers Viewpoint
-
批准号:17K04048
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
-
财政年份:2017
-
负责人:OZAWA Hiroshi
-
依托单位:
Low-energy extracorporeal shock wave therapy for improvement of locomotor and sensory functions after spinal cord injury
-
批准号:26462227
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2014
-
负责人:OZAWA Hiroshi
-
依托单位:
Development of Ultra-fast response Temperature-Sensitive-Paint capable of temperature measuring in 1ms test duration
-
批准号:25889047
-
项目类别:Grant-in-Aid for Research Activity Start-up
-
资助金额:$1.75万
-
财政年份:2013
-
负责人:OZAWA Hiroshi
-
依托单位:
Low-energy extracorporeal shock wave therapy promotes VEGF expression and neuroprotection and improves locomotor recovery after spinal cord injury
-
批准号:23592153
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2011
-
负责人:OZAWA Hiroshi
-
依托单位:
A Research on Conduct Code, Performance Evaluation, and Production System: Approach for fusion of engineering and accounting
-
批准号:21730297
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2009
-
负责人:OZAWA Hiroshi
-
依托单位:
Building a Quantitative Model on How production System is Decided and Case Study on How Production System had Changed
-
批准号:18730238
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.43万
-
财政年份:2006
-
负责人:OZAWA Hiroshi
-
依托单位:
A Sociocultural Study on Representations of the Mediterranean World in the English Renaissance Drama
-
批准号:12610515
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:2000
-
负责人:OZAWA Hiroshi
-
依托单位:
The Idea of the 'Alien' in English Literature
-
批准号:07301053
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.26万
-
财政年份:1995
-
负责人:OZAWA Hiroshi
-
依托单位:
海外基金