How dose the alteration in mechanical load due to change of alignment influence articular cartilage of knee joint

了解由于关节对位的改变而引起的机械负荷变化对膝关节关节软骨的影响是非常重要的。在本研究中，我们无法建立因膝关节排列改变而导致膝关节骨关节炎（OA）发病的动物模型。然而，我们发现自发发生膝关节OA的STR/OrtCrlj小鼠髌股关节的OA变化可能是由胫骨内扭转引起的。

It is very important to understand how the alteration in mechanical load due to change of alignment influences articular cartilage of knee joint. In this study we could not establish the animal model that had an onset of osteoarthritis (OA) of knee joint by change of knee alignment. However, we found that OA changes of the patellofemoral joint in STR/OrtCrlj mice that spontaneously developed knee OA may be caused by internal tibial torsion.