Human placental transfer of volatile anesthetic and its effect on the transfer of other drugs

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We studied placental transfer of Sevoflurane(S) and Isoflurane(I) with human placental cotyledon model. We summarized the study of five extracted placenta. As the result, the average(SD) of concentration ratio between maternal artery and fetal vein was 0.145(±0.07) in S, 0.144(±0.06) in I, then there was no significant difference(p=0.992). By examination of further study, we succeed getting samples from seven placentas to calculate antipyrine clearance. Now, we are writing the report.