Validation system for aging in human egg cells based on carbohydrate structures and in vitro maturation

基于碳水化合物结构和体外成熟的人类卵细胞衰老验证系统

• 批准号: 19591917
• 负责人: TOYODA Masashi
• 金额: $ 2.75万
• 依托单位: National Research Institute for Child Health and Development
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591917/
• 关键词: 糖鎖バリデーション; レクチン; 卵子; 発生

The molecular mechanism of maturation of ovum is not clear. For validation of mammalian egg maturation processes during development and aging, we investigated the cell surface carbohydrate expression patterns of ovum and ovary using carbohydrate specific antibodies and lectins. As a result, we showed that some specific carbohydrate structures had important roles for development and aging processes of ovum.

卵子成熟的分子机制尚不清楚。为了验证哺乳动物卵子在发育和老化过程中的成熟过程，我们使用碳水化合物特异性抗体和凝集素研究了卵子和卵巢细胞表面碳水化合物的表达模式。结果表明，某些特定的碳水化合物结构在卵子的发育和衰老过程中起着重要作用。