Investigation for ovarian cancer therapy focusing on production of human chorionic gonadotropin beta subunit

大多数卵巢癌患者都是在晚期确诊的。虽然卵巢癌的治疗包括手术治疗和联合化疗，但与耐药有关的预后仍然很差。作为上皮性卵巢癌的实验模型系统，我们建立了永生化的人卵巢表面上皮(OSE)细胞系。利用该体系，我们明确了人绒毛膜促性腺激素α亚基和β亚基在阻塞性睡眠呼吸暂停低密度脂蛋白细胞中的产生，以及hCGβ亚基在阻滞性生长中的作用。此外，许多卵巢癌组织也表达hCGβ亚单位。这一发现将为卵巢癌的治疗提供新的策略。

Most patients with ovarian cancer are diagnosed at an advanced stage. Although treatment for ovarian cancer consists of surgical treatment and combination chemotherapy, there is still poor prognosis associated with drug resistance. As an experimental model system for epithelial ovarian carcinogenesis, we established immortalized human ovarian surface epithelial (OSE) cell lines. Using this system, we clarified the production of hCG α subunit and β subunit in the OSE cells, and the effect of hCG β subunit in anchorage-independent growth of the OSE cells. Moreover, many ovarian cancer tissues also expressed hCG β subunit. This discovery will provide a development of new therapeutic strategies for ovarian cancer.