Novel strategy to control the differentiation of macrophages in ascites for the suppression of ovarian cancer dissemination

晚期上皮性卵巢癌（AdEOC）中的腹水巨噬细胞通过改变肿瘤微环境参与癌症转移和进展。我们研究了巨噬细胞在晚期上皮性卵巢癌腹水中的功能，以及巨噬细胞和EOC细胞之间通过Stat3活化的细胞间相互作用。腹水中的M2巨噬细胞可能通过激活STAT3影响上皮性卵巢癌的发展。巨噬细胞分化可作为抗肿瘤药物开发的靶点。此外，科罗索酸（CA），一种三萜类化合物，包含在巴拿巴植物（大叶紫薇）的叶中。该化合物具有多种生物学特性，包括抗糖尿病、抗肥胖和抗氧化活性。我们研究了CA对人卵巢癌细胞系的细胞毒性。CA通过抑制STAT3的活化抑制卵巢癌细胞的增殖。因此，CA可能成为一种潜在的肿瘤预防和治疗新工具。

Ascites macrophages in advanced epithelial ovarian cancer(AdEOC) are involved in cancer metastasis and progression by modifying the tumor microenvironment. We investigated the function of macrophages in the ascites of advanced epithelial ovarian cancers and the cell-to-cell interactions between macrophages and EOC cells through Stat3 activation. M2 macrohpages in the ascitic fluid may influence epithelial ovarian cancer development via STAT3 activation. Macrohages differentiation could be targeted for development of anticancer therapeutic drugs. Furthermore, corosolic acid(CA), a triterpenoid compound, is contained in the leaves of the banaba plant(Lagerstroemia speciosa L.). The compound possesses various biological properties, including anti-diabetic, anti-obesity and anti-oxidative activities. We investigated the cytotoxicity of CA against human ovarian cancer cell lines. CA inhibited the proliferation of ovarian cancer cells by suppressing the activation of STAT3. Therefore, CA might be a potential new tool for tumor prevention and therapy.