The elucidation and the strategy for multiple organ dysfunction syndrome following severe burn injury.

严重烧伤后的主要并发症之一是感染。这会导致高死亡率和住院时间的延长。早期肠内营养是保护免疫功能、减少并发症的重要手段。本研究采用临床常用的免疫调节性饮食，重点研究炎症状态下的脂肪酸代谢。首先对大鼠持续肠内营养相关的基础实验进行了研究。其次，采用核磁共振氢谱技术检测烫伤大鼠二次打击后内毒素刺激后代谢产物的变化。我们观察到不同组间代谢产物的不同峰值。

One of the major complications following severe burn is an infection.This causes increasing high mortality rate and prolonged hospital stay. Early enteral nutrition is an important to preserve immune function and decrease complications. This study focused metabolism of fatty acids under inflammation using imunomodulating diets which usually is used clinically. First we investigated the basal experiment related with a continuous enteral nutrition of rat. Second we tested to change of metabolites following LPS stimulation as second hit after burned rat using 1H-NMR. We observed the different peak of metabolites between the groups.