The elucidation and the strategy for multiple organ dysfunction syndrome following severe burn injury.

严重烧伤后的主要并发症之一是感染，这导致死亡率增高和住院时间延长。早期肠内营养对保护机体免疫功能、减少并发症的发生具有重要意义。本研究采用临床常用的免疫调节饮食，研究炎症状态下脂肪酸的代谢。本研究首先进行了大鼠持续肠内营养相关的基础实验。第二，用~ 1H-NMR检测了烧伤大鼠在LPS刺激后，作为二次打击时代谢产物的变化。我们观察到组间代谢产物的不同峰。

One of the major complications following severe burn is an infection.This causes increasing high mortality rate and prolonged hospital stay. Early enteral nutrition is an important to preserve immune function and decrease complications. This study focused metabolism of fatty acids under inflammation using imunomodulating diets which usually is used clinically. First we investigated the basal experiment related with a continuous enteral nutrition of rat. Second we tested to change of metabolites following LPS stimulation as second hit after burned rat using 1H-NMR. We observed the different peak of metabolites between the groups.