Visualization of the thermal energy change and the metabolism change in the body during sepsis

脓毒症期间体内热能变化和代谢变化的可视化

• 批准号: 22592024
• 负责人: SATO Norio
• 金额: $ 2.75万
• 依托单位: Kyoto University (2011-2012)Nippon Medical School (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592024/
• 关键词: 敗血症; 代謝動態; 免疫調整栄養剤; ホエイプロテイン; n-3系脂肪酸; 核磁気共鳴像; 栄養; 全身性炎症性反応症候群; エネルギー代謝; 全身炎症性反応症候群; 発熱; エネルギーリン代謝; 磁気共鳴画像

Sepsis is systemic inflammatory response syndrome (SIRS) caused by infection. Energy metabolism is remarkably aggravated and hyper catabolism resulted in protein breakdown. It is important to understand metabolic change in liver and muscle which are mainly related heat production. Nutrition is expected to suppress inflammatory reaction and improve metabolic changes. We successfully demonstrated metabolic changes between immune-modulating diet and control diet under septic insult using nuclear magnetic resonance.

脓毒症是由感染引起的全身炎症反应综合征（SIRS）。能量代谢明显加剧，高钙血症导致蛋白质分解。了解肝脏和肌肉中主要与产热有关的代谢变化是很重要的。营养有望抑制炎症反应并改善代谢变化。我们成功地证明了免疫调节饮食和对照饮食之间的代谢变化，脓毒症的侮辱使用核磁共振。