The role of phospholipase A2 in post-hemorrhagic shock mesenteric lymph on the development of distant organ injury.

本研究旨在探讨失血性休克后肠系膜淋巴(PSML)中磷脂酶A2在远隔器官损伤中的作用。肠系膜缺血在PSML中增加或产生PLA2蛋白。在双事件模型中，在体外和体内抑制PLA2可减弱PSML的中性粒细胞启动效应，预防急性肺损伤。

The purpose of this study is to determine the role of phospholipase A2 in post-hemorrhagic shock mesenteric lymph (PSML) on the development of distant organ injury. Mesenteric ischemia increases or generates PLA2 protein in PSML. PLA_2 inhibition, in vitro and in vivo, attenuates the neutrophil priming effect of PSML and prevents acute lung injury in a two-event model.