The role of gut derived arachidonic acid in post-hemorrhagic shock mesenteric lymph on the development of distant organ injury

本研究的目的是确定花生四烯酸在失血性休克后肠系膜淋巴液（PSML）中对远端器官损伤发展的作用。我们已经表明，肠系膜缺血产生磷脂酶A2蛋白在PSML，诱导中性粒细胞启动和急性肺损伤的两个事件模型。本研究旨在进一步探讨失血性休克后肠系膜淋巴液引起包括花生四烯酸在内的器官损伤的机制。

The purpose of this study is to determine the role of arachidonic acid in post-hemorrhagic shock mesenteric lymph (PSML) on the development of distant organ injury. We have shown that mesenteric ischemia generates phospholipase A2 protein in PSML, which induce neutrophil priming and acute lung injury in a two-event model. We have been investigating further mechanism of post-hemorrhagic shock mesenteric lymph inducedorgan injury including arachidonic acid.