The role of gut derived arachidonic acid in post-hemorrhagic shock mesenteric lymph on the development of distant organ injury

肠源性花生四烯酸在失血性休克后肠系膜淋巴中对远处器官损伤发展的作用

• 批准号: 22592025
• 负责人: MASUNO Tomohiko
• 金额: $ 2.83万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592025/
• 关键词: 腸管リンパ液; 脂質メディエータ; 腸管虚血; アラキドン酸; 臓器障害; 出血性ショック

The purpose of this study is to determine the role of arachidonic acid in post-hemorrhagic shock mesenteric lymph (PSML) on the development of distant organ injury. We have shown that mesenteric ischemia generates phospholipase A2 protein in PSML, which induce neutrophil priming and acute lung injury in a two-event model. We have been investigating further mechanism of post-hemorrhagic shock mesenteric lymph inducedorgan injury including arachidonic acid.

本研究旨在探讨失血性休克后肠系膜淋巴(PSML)中花生四烯酸在远隔器官损伤中的作用。我们已经证明，肠系膜缺血在PSML中产生磷脂酶A2蛋白，从而在两事件模型中诱导中性粒细胞启动和急性肺损伤。我们一直在进一步研究失血性休克后肠系膜淋巴导致器官损伤的机制，包括花生四烯酸。