The role of gut derived arachidonic acid in post-hemorrhagic shock mesenteric lymph on the development of distant organ injury

本研究的目的是确定花生四烯酸在失血性休克后肠系膜淋巴（PSML）中对远处器官损伤发展的作用。我们已经证明，肠系膜缺血在PSML中产生磷脂酶A2蛋白，在双事件模型中诱导中性粒细胞启动和急性肺损伤。我们正在进一步研究失血性休克后肠系膜淋巴诱导器官损伤的机制，包括花生四烯酸。

The purpose of this study is to determine the role of arachidonic acid in post-hemorrhagic shock mesenteric lymph (PSML) on the development of distant organ injury. We have shown that mesenteric ischemia generates phospholipase A2 protein in PSML, which induce neutrophil priming and acute lung injury in a two-event model. We have been investigating further mechanism of post-hemorrhagic shock mesenteric lymph inducedorgan injury including arachidonic acid.