Frontiers in the clarification of the muscular stem cell differentiation process involved in restoring muscle function

澄清参与恢复肌肉功能的肌肉干细胞分化过程的前沿

• 批准号: 19592131
• 负责人: ABE Shin-ichi
• 金额: $ 2.83万
• 依托单位: Tokyo Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592131/
• 关键词: 筋線維; 筋活性; 成長因子; 筋幹細胞; 筋原線維; 筋機能; 筋芽細胞; 筋収縮タンパク; 筋衛星細胞; 筋SP細胞; IGF-1; 遺伝子導入; 細胞内ストレス; 筋肥大; 細胞伸展

Decreased muscle function is a major cause of the deterioration of eating function including mastication and swallowing in the elderly. We evaluated two processes involved in the mechanism of restoring muscle function. In one process, muscle protein synthesis (promotion) exceeded its degradation (inhibition), and a resulting increase in muscle fiber thickness increases muscle tissue weight, and also improves muscle function. In the other process, muscle-specific stem cells produce new muscle fibers. Thus, the interaction of various factors is important.

肌肉功能下降是老年人咀嚼和吞咽等进食功能下降的主要原因。我们评估了恢复肌肉功能的机制中涉及的两个过程。在一个过程中，肌肉蛋白质的合成（促进）超过了其降解（抑制），由此导致的肌纤维厚度的增加增加了肌肉组织的重量，也改善了肌肉功能。在另一个过程中，肌肉特异性干细胞产生新的肌肉纤维。因此，各种因素的相互作用是重要的。