Frontiers in the clarification of the muscular stem cell differentiation process involved in restoring muscle function

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Decreased muscle function is a major cause of the deterioration of eating function including mastication and swallowing in the elderly. We evaluated two processes involved in the mechanism of restoring muscle function. In one process, muscle protein synthesis (promotion) exceeded its degradation (inhibition), and a resulting increase in muscle fiber thickness increases muscle tissue weight, and also improves muscle function. In the other process, muscle-specific stem cells produce new muscle fibers. Thus, the interaction of various factors is important.