Natural antisense of GTP cyclohydrolase 1 : physiological functions and expression mechanisms of the antisense RNA

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Tetrahydrobiopterin (BH4) is an essential cofactor for the enzymes which synthesize monoamine neurotransmitters and nitric oxide, thus influencing neuronal and vascular functions. We found in PC12 cells and in rat and mouse livers natural antisense RNA (naRNA) of GTP cyclohydrolase1 (GCH), a rate-limiting enzyme in BH4 de novo synthesis. When the PC12 cells were stimulated by various agents which increased the cellular BH4 level, GCH naRNA was increased in parallel with GCH mRNA.