Effects of sexual hormones for osteoclasts of temporomandibular joint disorders

性激素对颞下颌关节疾病破骨细胞的影响

• 批准号: 19592323
• 负责人: KANEYAMA Keiseki
• 金额: $ 2.91万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592323/
• 关键词: 顎関節症; 破骨細胞; 破骨細胞分化促進因子; 破骨細胞分化抑制因子; 滑液; 滑膜; ビスフェノールA; 性ホルモン; 顎関節; ビスフェノール; マウス; 下顎頭; 環境ホルモン; エストロゲン; 蛋白; 尿検査試験紙; pH; 滑幕; 破骨細胞分化因子(RANKL); 破骨細胞抑制因子(OPG); クレアチニン

To investigate the possible influences of estrogen on the development of osteoarthritis (OA), the effects of Bisphenol-A (BPA), an analogue of estrogen, on the development of the temporomandibular joints in mice fetuses were examined. The temporomandibular joints was reduced in volume and cell number in the BPA groups. The low concentration groups (0.2-2μg/kg) demonstrated the smallest volume and lowest cell number.BPA administration appeared to affect the development of the mandibular condyle in mice.

为了研究雌激素对骨关节炎（OA）发育的可能影响，研究了双酚-A（BPA）（雌激素的类似物）对小鼠胎儿颞下颌关节发展的发展。 BPA组的体积和细胞数量减少了模板符号的接头。低浓度组（0.2-2μg/kg）证明了最小的体积和最低的细胞数。BPA给药似乎影响小鼠下颌con的发展。