Effects of sexual hormones for osteoclasts of temporomandibular joint disorders

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To investigate the possible influences of estrogen on the development of osteoarthritis (OA), the effects of Bisphenol-A (BPA), an analogue of estrogen, on the development of the temporomandibular joints in mice fetuses were examined. The temporomandibular joints was reduced in volume and cell number in the BPA groups. The low concentration groups (0.2-2μg/kg) demonstrated the smallest volume and lowest cell number.BPA administration appeared to affect the development of the mandibular condyle in mice.