Analyses of physiological role of circadian clock in the ovary

卵巢生物钟的生理作用分析

• 批准号: 19599001
• 负责人: NAKAMURA Tomoko
• 金额: $ 2.76万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19599001/
• 关键词: 概日リズム; 末梢時計; 中枢時計; 卵巣; 黄体形成ホルモン; LHサージ; ルシフェラーゼレポーター; 発情周期

Current understanding in the field is that the circadian clock in the suprachiasmatic nucleus controls the phase of circadian clock in the peripheral organs. However, the mechanism of the control is remained to be shown. In this study, we used the rat ovary as a model of the peripheral organ, and investigated the potency of LH to control the phase of the circadian clock. When LH level was kept at a constant level in the rat by a pharmacological or surgical method, the amplitude of circadian oscillation was significantly decreased. The result indicates that LH is important to maintain circadian oscillation in the ovary.

目前该领域的理解是视交叉上核中的生物钟控制着周围器官中生物钟的相位。然而，控制机制仍有待阐明。在这项研究中，我们使用大鼠卵巢作为周围器官的模型，并研究了 LH 控制生物钟相位的效力。当通过药物或手术方法将大鼠体内的LH水平保持在恒定水平时，昼夜节律振荡的幅度显着降低。结果表明 LH 对于维持卵巢的昼夜节律振荡很重要。

项目成果

Clock mechanisms for seasonal adaptation : Morning and evening oscillators in the suprachiasmatic nucleus

季节适应的时钟机制：视交叉上核的早晨和晚上振荡器

• 发表时间: 2008
• 期刊: Sleep Biol. Rhythms 6
• 作者: Honma;S
• 通讯作者: S