Mechanism for regulation of innate immune responses

我们利用原生动物寄生虫感染和炎症性疾病两种体内模型分析了调节天然免疫活性的机制。在感染模型中，我们揭示了一种新的机制，即先天免疫诱导钙依赖的适应性免疫激活。在炎症性疾病模型中，我们使用了炎症性肠病模型，并揭示了独特的肠道固有免疫髓系细胞亚群通过诱导炎症和抗炎反应来调节肠道的动态平衡。

We analyzed the mechanisms by which activity of innate immunity is regulated using two in vivo models, protozoan parasite infections and inflammatory diseases. In infectious models, we revealed a novel mechanism in which innate immunity induces Ca2+-dependent activation of adaptive immunity. In inflammatory disease models, we used inflammatory bowel disease models, and revealed that unique subsets of intestinal innate immune myeloid cells regulate intestinal homeostasis through induction of inflammatory and anti-inflammatory responses.