Synthetic Studies on Biologically Functional Molecules

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Aiming for development of efficient synthetic routes toward natural products, which have been used as drugs, or which are expected as drug candidate, we initiated our synthetic programs. As a result, total synthesis of ecteinascidin 743, lysergic acid, huperzine A, salinosporamide and so on have been achieved. Based on the established synthetic routes, a variety of analogs of natural products and related molecules, which includes vinblastine, oseltamivir and so on have been synthesized.