Development of a New Cancer Diagnostic and Treatment Device by 3-D Imaging Techniques for Microvessels Using a Laser

我们研制了一种用于测量血液流动的激光多普勒测速仪，称为微型多点激光多普勒测速仪（μ MLDV）。μ MLDV主要用于诊断癌症。我们试图进行血流速度成像的恶性黑色素瘤已移植到耳朵的小鼠。利用该装置，我们成功地非侵入性地测量了微血管中的血流速度。此外，我们能够测量绝对速度，并在此基础上显示血管内的流动。进一步的实验证实了μ MLDV作为癌症治疗加热装置的能力。通过交叉两个激光束在恶性细胞部位产生过热来靶向癌症病变。实验结果表明，该装置有可能成为一种新的非侵入性诊断方法，用于区分良性痣和恶性黑色素瘤。

We have developed a laser Doppler velocimeter to measure blood flow, named the Micro-Multi point Laser Doppler Velocimeter (μ MLDV). The μ MLDV was developed primarily for use in the diagnosis of cancer. We attempted to perform blood flow velocity imaging of a malignant melanoma which had been transplanted in the ear of a mouse. With this device we have succeeded in non-invasively measuring the blood flow velocity in microvessels. Moreover, we are able to measure absolute velocity and based on this can display the flow within blood vessels. Further experimentation confirmed the ability for the μ MLDV to be used as a heating device for cancer treatment. Cancer lesions are targeted by crossing the two laser beams producing overheating at the site of the malignant cells. The experimental results suggest that this device has the potential to become a new non-invasive diagnostic method for distinguishing benign nevi from malignant melanomas.